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Proteins/UNIPROT:Q13873
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA..
Function from UniProtKB (Q13873), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 rows
96 statements
96 statements · 5 reference databases · Subject: BMPR2 · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways
2 reactions
6 names
Resolves to: BMPR2
Rhea RHEA:18673CC BY 4.0Reference data
L-threonyl-[receptor-protein]+ATP(4-)O-phospho-L-threonyl-[receptor-protein]+ADP(3-)+hydron
Catalysed by BMPR1B or ACVR2A or BMPR1A or ACVR1B or TGFBR1 or ACVRL1 or TGFBR2 or ACVR1 or ACVR2B or BMPR2 or AMHR2 or ACVR1C
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:44880CC BY 4.0Reference data