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Proteins/UNIPROT:Q6ZSB9
Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription..
[Isoform 1]: Binds CDKN1A promoter and activates its transcription; this activity is further potentiated in the presence of EP300 (synergistic) and ZBTB17/Miz-1 (additive)..
[Isoform 3]: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter..
Function from UniProtKB (Q6ZSB9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
122 statements
122 statements · 2 reference databases · Subject: ZBTB49 · Sources: gene ontology, Hetionet
3 names
Resolves to: ZBTB49