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Proteins/UNIPROT:Q9BUI4
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Part of POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer, coordinates the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner..
Function from UniProtKB (Q9BUI4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
85 statements
85 statements · 4 reference databases · Subject: POLR3C · Sources: gene ontology, Hetionet, Reactome, WikiPathways
2 reactions
4 names
Resolves to: POLR3C
Reaction pageLeft to rightBalance undeterminableEC 2.7.7.6, 2.7.7.19, 2.7.7.52nucleus
Human-GEM MAR07161CC BY 4.0Reference data
phosphate(3-)+MAM02847c0.18ADP+0.3CHEBI:17239+0.34GDP+0.18UDP
Catalysed by POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & PAPOLA & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT7 & POLR3C & POLR1E & POLR3F & POLR1B & POLR3E & MTPAP & POLR3B & POLR1H & POLR3K & POLR3H or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & PAPOLA & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT4 & POLR3C & POLR1E & POLR3F & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & PAPOLA & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & POLR3C & POLR1E & POLR3F & TUT1 & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT7 & POLR3C & PAPOLG & POLR1E & POLR3F & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT4 & POLR3C & PAPOLG & POLR1E & POLR3F & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & POLR3C & PAPOLG & POLR1E & POLR3F & TUT1 & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT7 & TENT2 & POLR3C & POLR1E & POLR3F & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT4 & TENT2 & POLR3C & POLR1E & POLR3F & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TENT2 & POLR3C & POLR1E & POLR3F & TUT1 & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT7 & POLR3C & POLR1E & POLR3F & POLR1B & PAPOLB & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT4 & POLR3C & POLR1E & POLR3F & POLR1B & PAPOLB & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & POLR3C & POLR1E & POLR3F & TUT1 & POLR1B & PAPOLB & POLR3E & and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.7.7.8cytosol
Human-GEM MAR07162CC BY 4.0Reference data