Loading the page.
Proteins/UNIPROT:P37088
This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis. ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically. It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance..
[Isoform 4]: Not functional..
Function from UniProtKB (P37088), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
4 rows
149 statements
149 statements · 6 reference databases · Subject: SCNN1A · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
Transported by SCN1A or SCN2A or SCN3A or SCN4A or SCN5A or SCN7A or SCN8A or SCN9A or SCN10A or SCN11A or HCN1 or HCN4 and 5 more alternatives
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR01527CC BY 4.0Reference data
10 names
Resolves to: SCNN1A
Transported by ANO9 or HTR3E or TMEM150C or KCNK1 or KCNK3 or GRIN2D or GRID2 or KCNQ3 or KCNQ2 or GRIN3B or HCN1 or TRPA1 and 98 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:34963CC BY 4.0Reference data