Proteins/UNIPROT:Q12974

PTP4A2

ProteinUNIPROT:Q12974

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB..

Function from UniProtKB (Q12974), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

27 statements

27 statements · 2 reference databases · Subject: PTP4A2 · Sources: Hetionet, Reactome

Order

ACTG1 covaries with PTP4A2ProteinHetionet hetionet:covaries:71-8073Inferred only
ACTN1 covaries with PTP4A2ProteinHetionet hetionet:covaries:8073-87Inferred only
ARMCX3 covaries with PTP4A2ProteinHetionet hetionet:covaries:51566-8073Inferred only
FKBP2 covaries with PTP4A2ProteinHetionet hetionet:covaries:2286-8073Inferred only
H2BC4; H2BC6; H2BC7; H2BC8; H2BC10 covaries with PTP4A2ProteinHetionet hetionet:covaries:8073-8339Inferred only
MAPRE3 covaries with PTP4A2ProteinHetionet hetionet:covaries:22924-8073Inferred only
MED22 covaries with PTP4A2ProteinHetionet hetionet:covaries:6837-8073Inferred only
NRXN2 covaries with PTP4A2ProteinHetionet hetionet:covaries:8073-9379Inferred only
RAB10 covaries with PTP4A2ProteinHetionet hetionet:covaries:10890-8073Inferred only
SERPINH1 covaries with PTP4A2ProteinHetionet hetionet:covaries:8073-871Inferred only
SERTM1 covaries with PTP4A2ProteinHetionet hetionet:covaries:400120-8073Inferred only
SIX2 covaries with PTP4A2ProteinHetionet hetionet:covaries:10736-8073Inferred only

Show the remaining 15

SRP54 covaries with PTP4A2ProteinHetionet hetionet:covaries:6729-8073Inferred only
THOC7 covaries with PTP4A2ProteinHetionet hetionet:covaries:80145-8073Inferred only
TMEM106B covaries with PTP4A2ProteinHetionet hetionet:covaries:54664-8073Inferred only
ZNF32 covaries with PTP4A2ProteinHetionet hetionet:covaries:7580-8073Inferred only
ZNF524 covaries with PTP4A2ProteinHetionet hetionet:covaries:147807-8073Inferred only
ZNF580 covaries with PTP4A2ProteinHetionet hetionet:covaries:51157-8073Inferred only
PTP4A2 interacts with ATF7ProteinHetionet hetionet:interacts:11016-8073Inferred only
MLH1 interacts with PTP4A2ProteinHetionet hetionet:interacts:4292-8073Inferred only
RABGGTB interacts with PTP4A2ProteinHetionet hetionet:interacts:5876-8073Inferred only
PTP4A2 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
PTP4A2 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
PTP4A2 participates in RAB geranylgeranylationPathwayReactome R-HSA-8873719Inferred only
POLR2E decreases the expression of PTP4A2ProteinHetionet hetionet:regulates:5434-8073Inferred only
PXN decreases the expression of PTP4A2ProteinHetionet hetionet:regulates:5829-8073Inferred only
RAF1 decreases the expression of PTP4A2ProteinHetionet hetionet:regulates:5894-8073Inferred only

Reactions

1 reaction

O-phospho-L-tyrosyl-[protein]+waterL-tyrosyl-[protein]+hydrogenphosphate
Catalysed by PGP or EYA2 or PTPRT or CDC14B or PTP4A3 or DUSP14 or EPM2A or EYA4 or PTPRC or PTPRF or ACP3 or PTPN2 and 71 more alternatives
Reaction pageLeft to rightBalance undeterminable

Other names

8 names

Resolves to: PTP4A2

Also called: HU-PP-1OV-1PRL-2PRL2Protein-tyrosine phosphatase 4a2Protein-tyrosine phosphatase of regenerating liver 2PTP(CAAXII)PTPCAAX2

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