FBXO28

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, promoting ubiquitination and proteasomal degradation of specific target proteins including TOP2A, RAB27A or itself. Regulates topoisomerase IIalpha/TOP2A decatenation activity and plays an important role in maintaining genomic stability. Plays a role in lipid metabolism and inflammation through the ubiquitinated degradation of RAB27A (By similarity). Strongly regulates beta-cell survival without having any significant independent effect on insulin secretion. Plays an essential role in spindle morphology and actin-based spindle migration probably through the ARPC2/ARP3 signaling pathway (By similarity)..

Function from UniProtKB (Q9NVF7), read 2026-09-23. CC BY 4.0.