Pathway
mRNA Capping
The 5'-ends of all eukaryotic pre-mRNAs studied thus far are converted to cap structures. The cap is thought to influence splicing of the first intron, and is bound by 'cap-binding' proteins, CBP80 and CBP20, in the nucleus. The cap is important for translation initiation, and it also interacts with the poly(A)terminus, via proteins, resulting in circularization of the mRNA to facilitate multiple rounds of translation. The cap is also important for mRNA stability, protecting it from 5' to 3' nucleases, and is required for mRNA export to the cytoplasm.
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The capping reaction usually occurs very rapidly on nascent transcripts; after the synthesis of only a few nucleotides by RNA polymerase II. The capping reaction involves the conversion of the 5'-end of the nascent transcript from a triphosphate to a diphosphate by a RNA 5'-triphosphatase, followed by the addition of a guanosine monophosphate by the mRNA guanylyltransferase, to form a 5'-5'-triphosphate linkage. This cap is then methylated by 2'-O-methyltransferases.
What the reference databases state
Statements
30 statements
30 statements · 1 reference database · Subject: mRNA Capping · Sources: Reactome
- CCNH participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- CDK7 participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- ERCC2 participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- ERCC3 participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- GTF2F1 participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- GTF2F2 participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- GTF2H1 participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- GTF2H2 participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- GTF2H3 participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- GTF2H4 participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- GTF2H5 participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- MNAT1 participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
Show the remaining 18
- NCBP1 participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- NCBP2 participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- POLR2A participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- POLR2B participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- POLR2C participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- POLR2D participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- POLR2E participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- POLR2F participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- POLR2G participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- POLR2H participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- POLR2I participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- POLR2J participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- POLR2K participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- POLR2L participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- RAMAC participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- RNGTT participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- RNMT participates in mRNA CappingProteinReactome R-HSA-72086Inferred only
- SUPT5H participates in mRNA CappingProteinReactome R-HSA-72086Inferred only