Proteins/UNIPROT:Q9NVU0

POLR3E

ProteinUNIPROT:Q9NVU0

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Assembles with POLR3D/RPC4 forming a subcomplex that binds the Pol III core. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway..

Function from UniProtKB (Q9NVU0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

46 statements

46 statements · 3 reference databases · Subject: POLR3E · Sources: Hetionet, Reactome, WikiPathways

Order

HS3ST1 covaries with POLR3EProteinHetionet hetionet:covaries:55718-9957Inferred only
POLR3A interacts with POLR3EProteinHetionet hetionet:interacts:11128-55718Inferred only
POLR3D interacts with POLR3EProteinHetionet hetionet:interacts:55718-661Inferred only
SUMO2 interacts with POLR3EProteinHetionet hetionet:interacts:55718-6613Inferred only
UBC interacts with POLR3EProteinHetionet hetionet:interacts:55718-7316Inferred only
POLR3E participates in 16p12 2 copy number variation syndrome 520kb PathwayWikiPathways WP5510Inferred only
POLR3E participates in Cytosolic DNA sensing pathwayPathwayWikiPathways WP4655Inferred only
POLR3E participates in Cytosolic sensors of pathogen-associated DNAPathwayReactome R-HSA-1834949Inferred only
POLR3E participates in Eukaryotic transcription initiationPathwayWikiPathways WP405Inferred only
POLR3E participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
POLR3E participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
POLR3E participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only

Show the remaining 34

POLR3E participates in Pyrimidine metabolismPathwayWikiPathways WP4022Inferred only
POLR3E participates in RNA Polymerase III Abortive And Retractive InitiationPathwayReactome R-HSA-749476Inferred only
POLR3E participates in RNA Polymerase III Chain ElongationPathwayReactome R-HSA-73780Inferred only
POLR3E participates in RNA Polymerase III TranscriptionPathwayReactome R-HSA-74158Inferred only
POLR3E participates in RNA Polymerase III Transcription InitiationPathwayReactome R-HSA-76046Inferred only
POLR3E participates in RNA Polymerase III Transcription Initiation From Type 1 PromoterPathwayReactome R-HSA-76061Inferred only
POLR3E participates in RNA Polymerase III Transcription Initiation From Type 2 PromoterPathwayReactome R-HSA-76066Inferred only
POLR3E participates in RNA Polymerase III Transcription Initiation From Type 3 PromoterPathwayReactome R-HSA-76071Inferred only
POLR3E participates in RNA Polymerase III Transcription TerminationPathwayReactome R-HSA-73980Inferred only
POLR3E decreases the expression of ARHGAP1ProteinHetionet hetionet:regulates:55718-392Inferred only
CHERP increases the expression of POLR3EProteinHetionet hetionet:regulates:10523-55718Inferred only
POLR3E increases the expression of CRIP1ProteinHetionet hetionet:regulates:55718-1396Inferred only
POLR3E decreases the expression of DPYSL2ProteinHetionet hetionet:regulates:55718-1808Inferred only
POLR3E decreases the expression of GDF15ProteinHetionet hetionet:regulates:55718-9518Inferred only
POLR3E decreases the expression of GOLT1BProteinHetionet hetionet:regulates:55718-51026Inferred only
HOOK2 increases the expression of POLR3EProteinHetionet hetionet:regulates:29911-55718Inferred only
ID2 increases the expression of POLR3EProteinHetionet hetionet:regulates:3398-55718Inferred only
POLR3E decreases the expression of LRRC41ProteinHetionet hetionet:regulates:55718-10489Inferred only
POLR3E decreases the expression of NME1ProteinHetionet hetionet:regulates:55718-4830Inferred only
POLR3E decreases the expression of NPDC1ProteinHetionet hetionet:regulates:55718-56654Inferred only
POLR3E decreases the expression of NPTX2ProteinHetionet hetionet:regulates:55718-4885Inferred only
PABPC1 increases the expression of POLR3EProteinHetionet hetionet:regulates:26986-55718Inferred only
POLR3E decreases the expression of PGAM1ProteinHetionet hetionet:regulates:55718-5223Inferred only
POLR3E increases the expression of PLCB3ProteinHetionet hetionet:regulates:55718-5331Inferred only
PSMD3 increases the expression of POLR3EProteinHetionet hetionet:regulates:5709-55718Inferred only
POLR3E increases the expression of RAB31ProteinHetionet hetionet:regulates:55718-11031Inferred only
POLR3E decreases the expression of RBM34ProteinHetionet hetionet:regulates:55718-23029Inferred only
POLR3E decreases the expression of RPS4Y1ProteinHetionet hetionet:regulates:55718-6192Inferred only
POLR3E decreases the expression of SPON2ProteinHetionet hetionet:regulates:55718-10417Inferred only
POLR3E decreases the expression of STUB1ProteinHetionet hetionet:regulates:55718-10273Inferred only
TOMM70 increases the expression of POLR3EProteinHetionet hetionet:regulates:9868-55718Inferred only
POLR3E decreases the expression of TRAK2ProteinHetionet hetionet:regulates:55718-66008Inferred only
TWF2 increases the expression of POLR3EProteinHetionet hetionet:regulates:11344-55718Inferred only
POLR3E decreases the expression of TXNDC9ProteinHetionet hetionet:regulates:55718-10190Inferred only

Reactions

2 reactions

0.18ATP+0.3CHEBI:17677+0.34GTP+0.18UTPdiphosphate(3-)+MAM02847n
Catalysed by POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & PAPOLA &

Other names

3 names

Resolves to: POLR3E

Also called: DNA-directed RNA polymerase III 80 kDa polypeptideKIAA1452RNA polymerase III subunit C5

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