Pathway
RNA Polymerase I Transcription
RNA polymerase (Pol) I (one of three eukaryotic nuclear RNA polymerases) is devoted to the transcription of the ribosomal DNA genes, which are found in multiple arrayed copies in every eukaryotic cell. These genes encode for the large ribosomal RNA precursor, which is then processed into the three largest subunits of the ribosomal RNA, the 18S, 28S, and 5.8S RNAs. In human cells the rDNA gene clusters are localized on the short arm of the five pairs of the acrocentric chromosomes. The rRNA promoter has two essential and specially spaced sequences: a CORE element and an upstream control element (UCE, also called UPE). The CORE element of the human promoter overlaps with the transcription start site, extending from 20 to 45, and is required for specific initiation of transcription.
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The polymerase is a multisubunit complex, composed of two large subunits (the most conserved portions include the catalytic site that shares similarity with other eukaryotic and bacterial multisubunit RNA polymerases) and a number of smaller subunits. Under a number of experimental conditions the core is competent to mediate ribonucleic acid synthesis, in vivo however, it requires additional factors to select the appropriate template. In humans the RNA transcript (45S) is approximately 13,000 nucleotides long. Before leaving the nucleus as assembled ribosomal particles, the 45S rRNA is cleaved to give one copy each of the 28S rRNA, the 18S rRNA, and the 5.8S rRNA. Equal quantities of the three rRNAs are produced by initially transcribing them as one transcript.
REACT:R-HSA-73864Reactome
What the reference databases state
Statements
77 statements
77 statements · 1 reference database · Subject: RNA Polymerase I Transcription · Sources: Reactome
- CAVIN1 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- CBX3 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- CCNH participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- CDK7 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- CHD3 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- CHD4 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- EHMT2 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- ERCC2 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- ERCC3 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- ERCC6 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- GATAD2A participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- GATAD2B participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
Show the remaining 65
- GTF2H1 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- GTF2H2 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- GTF2H3 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- GTF2H4 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- GTF2H5 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H2AB1 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H2AC14 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H2AC18; H2AC19 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H2AC20 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H2AC4; H2AC8 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H2AC6 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H2AC7 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H2AJ participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H2AX participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H2AZ2 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H2BC1 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H2BC11 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H2BC12 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H2BC13 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H2BC14 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H2BC15 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H2BC17 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H2BC21 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H2BC26 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H2BC3 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H2BC4; H2BC6; H2BC7; H2BC8; H2BC10 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H2BC9 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H3-3A; H3-3B participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H3C15; H3C14; H3C13 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- HDAC1 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- HDAC2 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- KAT2A participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- KAT2B participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- MAPK3 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- MBD2 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- MBD3 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- MNAT1 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- MTA1 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- MTA2 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- MTA3 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- PHF6 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- POLR1A participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- POLR1B participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- POLR1C participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- POLR1E participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- POLR1F participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- POLR1G participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- POLR1H participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- POLR2E participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- POLR2F participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- POLR2H participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- POLR2K participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- POLR2L participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- RBBP4 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- RBBP7 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- RRN3 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- TAF1A participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- TAF1B participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- TAF1C participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- TAF1D participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- TBP participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- TTF1 participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only
- UBTF participates in RNA Polymerase I TranscriptionProteinReactome R-HSA-73864Inferred only