Pathway
RNA Polymerase II Pre-transcription Events
For initiation, Pol II assembles with the general transcription factors TFIIB, TFIID, TFIIE, TFIIF and TFIIH, which are collectively known as the general transcription factors, at promoter DNA to form the pre-initiation complex (PIC). Until the nascent transcript is about 15 nucleotides long, the early transcribing complex is functionally unstable. In the beginning, short RNAs are frequently released and Pol II has to restart transcription (abortive cycling). There is a decline in the level of abortive transcription when the RNA reaches a length of about four nucleotides, and this transition is termed escape commitment
REACT:R-HSA-674695Reactome
What the reference databases state
Statements
82 statements
82 statements · 1 reference database · Subject: RNA Polymerase II Pre-transcription Events · Sources: Reactome
- AFF4 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- CCNH participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- CCNK participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- CCNT1 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- CCNT2 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- CDC73 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- CDK7 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- CDK9 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- CTDP1 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- CTR9 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- EAF1 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- EAF2 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
Show the remaining 70
- ELL participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- ELOA participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- ELOA2 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- ELOB participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- ELOC participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- ERCC2 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- ERCC3 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- GTF2A1 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- GTF2A2 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- GTF2B participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- GTF2E1 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- GTF2E2 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- GTF2F1 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- GTF2F2 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- GTF2H1 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- GTF2H2 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- GTF2H3 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- GTF2H4 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- GTF2H5 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- IWS1 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- LEO1 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- MLLT1 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- MLLT3 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- MNAT1 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- NCBP1 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- NCBP2 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- NELFA participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- NELFB participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- NELFCD participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- NELFE participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- PAF1 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- POLR2A participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- POLR2B participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- POLR2C participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- POLR2D participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- POLR2E participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- POLR2F participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- POLR2G participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- POLR2H participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- POLR2I participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- POLR2J participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- POLR2K participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- POLR2L participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- RTF1 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- SKIC8 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- SSRP1 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- SUPT16H participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- SUPT4H1 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- SUPT5H participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- SUPT6H participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- TAF1 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- TAF10 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- TAF11 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- TAF12 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- TAF13 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- TAF15 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- TAF1L participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- TAF2 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- TAF3 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- TAF4 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- TAF4B participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- TAF5 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- TAF6 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- TAF7 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- TAF7L participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- TAF8 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- TAF9 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- TAF9B participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- TBP participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only
- TCEA1 participates in RNA Polymerase II Pre-transcription EventsProteinReactome R-HSA-674695Inferred only