Pathway
Cytosolic sensors of pathogen-associated DNA
Presence of pathogen-associated DNA in cytosol induces type I IFN production. Several intracellular receptors have been implicated to some degree. These include DNA-dependent activator of interferon (IFN)-regulatory factors (DAI) (also called Z-DNA-binding protein 1, ZBP1), absent in melanoma 2 (AIM2), RNA polymerase III (Pol III), IFN-inducible protein IFI16, leucine-rich repeat flightless interacting protein-1 (LRRFIP1), DEAH-box helicases (DHX9 and DHX36), DEAD-box helicase DDX41, meiotic recombination 11 homolog A (MRE11), DNA-dependent protein kinase (DNA-PK), cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING).
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Detection of cytosolic DNA requires multiple and possibly redundant sensors leading to activation of the transcription factor NF-kappaB and TBK1-mediated phosphorylation of the transcription factor IRF3. Cytosolic DNA also activates caspase-1-dependent maturation of the pro-inflammatory cytokines interleukin IL-1beta and IL-18. This pathway is mediated by AIM2.
REACT:R-HSA-1834949Reactome
What the reference databases state
Statements
63 statements
63 statements · 1 reference database · Subject: Cytosolic sensors of pathogen-associated DNA · Sources: Reactome
- AIM2 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- CGAS participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- CHUK participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- CRCP participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- CREBBP participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- CTNNB1 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- DDX41 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- DHX36 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- DHX9 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- DTX4 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- EP300 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- IFI16 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
Show the remaining 51
- IKBKB participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- IKBKG participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- IRF3 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- IRF7 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- LRRFIP1 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- MRE11 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- MYD88 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- NFKB1 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- NFKB2 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- NFKBIA participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- NFKBIB participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- NKIRAS1 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- NKIRAS2 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- NLRC3 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- NLRP4 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- POLR1C participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- POLR2E participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- POLR2F participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- POLR2H participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- POLR2K participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- POLR2L participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- POLR3A participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- POLR3B participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- POLR3C participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- POLR3D participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- POLR3E participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- POLR3F participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- POLR3G participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- POLR3GL participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- POLR3H participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- POLR3K participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- PRKDC participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- RELA participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- RIPK1 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- RIPK3 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- RPS27A participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- STAT6 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- STING1 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- TBK1 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- TICAM1 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- TLR3 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- TREX1 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- TRIM21 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- TRIM32 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- TRIM56 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- UBA52 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- UBB participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- UBC participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- XRCC5 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- XRCC6 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only
- ZBP1 participates in Cytosolic sensors of pathogen-associated DNAProteinReactome R-HSA-1834949Inferred only