Pathway
RNA Polymerase II Transcription Initiation
Formation of the open complex exposes the template strand to the catalytic center of the RNA polymerase II enzyme. This facilitates formation of the first phosphodiester bond, which marks transcription initiation. As a result of this, the TFIIB basal transcription factor dissociates from the initiation complex.
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The open transcription initiation complex is unstable and can revert to the closed state. Initiation at this stage requires continued (d)ATP-hydrolysis by TFIIH. Dinucleotide transcripts are not stably associated with the transcription complex. Upon dissociation they form abortive products. The transcription complex is also sensitive to inhibition by small oligo-nucleotides.
Dinucleotides complementary to position -1 and +1 in the template can also direct first phosphodiester bond formation. This reaction is independent on the basal transcription factors TFIIE and TFIIH and does not involve open complex formation. This reaction is sensitive to inhibition by single-stranded oligonucleotides.
REACT:R-HSA-75953Reactome
What the reference databases state
Statements
48 statements
48 statements · 1 reference database · Subject: RNA Polymerase II Transcription Initiation · Sources: Reactome
- CCNH participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- CDK7 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- ERCC2 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- ERCC3 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- GTF2A1 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- GTF2A2 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- GTF2B participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- GTF2E1 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- GTF2E2 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- GTF2F1 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- GTF2F2 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- GTF2H1 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
Show the remaining 36
- GTF2H2 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- GTF2H3 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- GTF2H4 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- GTF2H5 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- MNAT1 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- POLR2A participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- POLR2B participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- POLR2C participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- POLR2D participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- POLR2E participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- POLR2F participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- POLR2G participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- POLR2H participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- POLR2I participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- POLR2J participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- POLR2K participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- POLR2L participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- TAF1 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- TAF10 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- TAF11 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- TAF12 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- TAF13 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- TAF15 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- TAF1L participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- TAF2 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- TAF3 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- TAF4 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- TAF4B participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- TAF5 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- TAF6 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- TAF7 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- TAF7L participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- TAF8 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- TAF9 participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- TAF9B participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only
- TBP participates in RNA Polymerase II Transcription InitiationProteinReactome R-HSA-75953Inferred only