Proteins/UNIPROT:Q9H6E5

TUT1

ProteinUNIPROT:Q9H6E5Speckle targeted PIP5K1A-regulated poly(A) polymerase

Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation..

Function from UniProtKB (Q9H6E5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

13 statements

13 statements · 4 reference databases · Subject: TUT1 · Sources: gene ontology, Hetionet, Reactome, UniProt

Order

TUT1 covaries with CCDC34ProteinHetionet hetionet:covaries:64852-91057Inferred only
CCHCR1 covaries with TUT1ProteinHetionet hetionet:covaries:54535-64852Inferred only
CLEC3B covaries with TUT1ProteinHetionet hetionet:covaries:64852-7123Inferred only
MEPCE interacts with TUT1ProteinHetionet hetionet:interacts:56257-64852Inferred only
TIMELESS interacts with TUT1ProteinHetionet hetionet:interacts:64852-8914Inferred only
UBC interacts with TUT1ProteinHetionet hetionet:interacts:64852-7316Inferred only
TUT1 participates in Metabolism of RNAPathwayReactome R-HSA-8953854Inferred only
TUT1 participates in mRNA 3'-end processingPathwayReactome R-HSA-72187Inferred only
TUT1 participates in mRNA PolyadenylationPathwayReactome R-HSA-9770562Inferred only
TUT1 participates in Processing of Capped Intron-Containing Pre-mRNAPathwayReactome R-HSA-72203Inferred only
TUT1 regulates regulation of RNA metabolic processBiological processgene ontology Q9H6E5|GO:0051252Inferred only
TUT1 requires the cofactor magnesium(2+)CompoundUniProt Q9H6E5Inferred only

Show the remaining 1

TUT1 requires the cofactor Mn(2+)CompoundUniProt Q9H6E5Inferred only

Reactions

4 reactions

0.18ATP+0.3CHEBI:17677+0.34GTP+0.18UTPdiphosphate(3-)+MAM02847n
Catalysed by POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & PAPOLA &

Other names

7 names

Resolves to: TUT1

Also called: ARBM21RNA-binding motif protein 21RNA-binding protein 21Star-PAPU6 snRNA-specific terminal uridylyltransferase 1U6-TUTase

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