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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q9Y535

POLR3H

Protein·UNIPROT:Q9Y535

Open in the graph

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With CRCP/RPC9 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway..

Function from UniProtKB (Q9Y535), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

46 XX gonadal dysgenesis has a germline basis in POLR3HDiseaseGenCC HGNC:30349|MONDO:0009299Inferred only
primary ovarian failure has a germline basis in POLR3HDiseaseGenCC HGNC:30349|MONDO:0005387Inferred only

Statements

18 statements

18 statements · 3 reference databases · Subject: POLR3H · Sources: Hetionet, Reactome, WikiPathways

Search this listOrder

CRCP interacts with POLR3HProteinHetionet hetionet:interacts:171568-27297Inferred only
UBC interacts with POLR3HProteinHetionet hetionet:interacts:171568-7316Inferred only
POLR3H participates in Cytosolic DNA sensing pathwayPathwayWikiPathways WP4655Inferred only
POLR3H participates in Cytosolic sensors of pathogen-associated DNAPathwayReactome R-HSA-1834949Inferred only
POLR3H participates in Eukaryotic transcription initiationPathwayWikiPathways WP405Inferred only
POLR3H participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
POLR3H participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
POLR3H participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
POLR3H participates in Primary ovarian insufficiencyPathwayWikiPathways WP5461Inferred only
POLR3H participates in Pyrimidine metabolismPathwayWikiPathways WP4022Inferred only
POLR3H participates in RNA Polymerase III Abortive And Retractive InitiationPathwayReactome R-HSA-749476Inferred only
POLR3H participates in RNA Polymerase III Chain ElongationPathwayReactome R-HSA-73780Inferred only

Show the remaining 6

POLR3H participates in RNA Polymerase III TranscriptionPathwayReactome R-HSA-74158Inferred only
POLR3H participates in RNA Polymerase III Transcription InitiationPathwayReactome R-HSA-76046Inferred only
POLR3H participates in RNA Polymerase III Transcription Initiation From Type 1 PromoterPathwayReactome R-HSA-76061Inferred only
POLR3H participates in RNA Polymerase III Transcription Initiation From Type 2 PromoterPathwayReactome R-HSA-76066Inferred only
POLR3H participates in RNA Polymerase III Transcription Initiation From Type 3 PromoterPathwayReactome R-HSA-76071Inferred only
POLR3H participates in RNA Polymerase III Transcription TerminationPathwayReactome R-HSA-73980Inferred only

Reactions

2 reactions

0.18ATP+0.3CHEBI:17677+0.34GTP+0.18UTPdiphosphate(3-)+MAM02847n
Catalysed by POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & PAPOLA &

Other names

6 names

Resolves to: POLR3H

Also called: DNA-directed RNA polymerase III subunit HKIAA1665RNA polymerase III subunit 22.9 kDa subunitRNA polymerase III subunit C8RPC22.9RPC8

← Every protein Find it in the graph →

or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & PAPOLA & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT4 & POLR3C & POLR1E & POLR3F & POLR1B & POLR3E & MTPAP & POLR3B & POLR1H & POLR3K & POLR3H

or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & PAPOLA & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & POLR3C & POLR1E & POLR3F & TUT1 & POLR1B & POLR3E & MTPAP & POLR3B & POLR1H & POLR3K & POLR3H

or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT7 & POLR3C & PAPOLG & POLR1E & POLR3F & POLR1B & POLR3E & MTPAP & POLR3B & POLR1H & POLR3K & POLR3H

or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT4 & POLR3C & PAPOLG & POLR1E & POLR3F & POLR1B & POLR3E & MTPAP & POLR3B & POLR1H & POLR3K & POLR3H

or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & POLR3C & PAPOLG & POLR1E & POLR3F & TUT1 & POLR1B & POLR3E & MTPAP & POLR3B & POLR1H & POLR3K & POLR3H

or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT7 & TENT2 & POLR3C & POLR1E & POLR3F & POLR1B & POLR3E & MTPAP & POLR3B & POLR1H & POLR3K & POLR3H

or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT4 & TENT2 & POLR3C & POLR1E & POLR3F & POLR1B & POLR3E & MTPAP & POLR3B & POLR1H & POLR3K & POLR3H

or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TENT2 & POLR3C & POLR1E & POLR3F & TUT1 & POLR1B & POLR3E & MTPAP & POLR3B & POLR1H & POLR3K & POLR3H

or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT7 & POLR3C & POLR1E & POLR3F & POLR1B & PAPOLB & POLR3E & MTPAP & POLR3B & POLR1H & POLR3K & POLR3H

or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT4 & POLR3C & POLR1E & POLR3F & POLR1B & PAPOLB & POLR3E & MTPAP & POLR3B & POLR1H & POLR3K & POLR3H

or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & POLR3C & POLR1E & POLR3F & TUT1 & POLR1B & PAPOLB & POLR3E & MTPAP & POLR3B & POLR1H & POLR3K & POLR3H

and 12 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 2.7.7.6, 2.7.7.19, 2.7.7.52nucleus

Human-GEM MAR07161CC BY 4.0Reference data

phosphate(3-)+MAM02847c0.18ADP+0.3CHEBI:17239+0.34GDP+0.18UDP

Catalysed by POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & PAPOLA & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT7 & POLR3C & POLR1E & POLR3F & POLR1B & POLR3E & MTPAP & POLR3B & POLR1H & POLR3K & POLR3H or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & PAPOLA & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT4 & POLR3C & POLR1E & POLR3F & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & PAPOLA & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & POLR3C & POLR1E & POLR3F & TUT1 & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT7 & POLR3C & PAPOLG & POLR1E & POLR3F & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT4 & POLR3C & PAPOLG & POLR1E & POLR3F & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & POLR3C & PAPOLG & POLR1E & POLR3F & TUT1 & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT7 & TENT2 & POLR3C & POLR1E & POLR3F & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT4 & TENT2 & POLR3C & POLR1E & POLR3F & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TENT2 & POLR3C & POLR1E & POLR3F & TUT1 & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT7 & POLR3C & POLR1E & POLR3F & POLR1B & PAPOLB & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT4 & POLR3C & POLR1E & POLR3F & POLR1B & PAPOLB & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & POLR3C & POLR1E & POLR3F & TUT1 & POLR1B & PAPOLB & POLR3E & and 12 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 2.7.7.8cytosol

Human-GEM MAR07162CC BY 4.0Reference data