Pathway
Negative epigenetic regulation of rRNA expression
Transcription of rRNA genes is controlled by epigenetic activation and repression (reviewed in McStay and Grummt 2008, Goodfellow and Zomerdijk 2012, Grummt and Langst 2013). About half of the roughly 400 rRNA genes are expressed and these have the modifications of active chromatin: unmethylated DNA and acetylated histones. Repressed genes generally have methylated DNA and histone H3 methylated at lysine-9. Regulators of repression include the eNoSC complex, SIRT1, and the NoRC complex.
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SIRT1 negatively regulates rRNA expression as a subunit of the eNoSC complex, which deacetylates histone H3 and dimethylates lysine-9 of histone H3 (H3K9me2).
NoRC negatively regulates rRNA expression by shifting a nucleosome near the start of rRNA transcription into a more repressive location and recruiting Histone Deacetylase 1 and 2 (HDAC1, HDAC2) and DNA Methyltransferase 1 and 3b (DNMT1, DNMT3b).
REACT:R-HSA-5250941Reactome
What the reference databases state
Statements
74 statements
74 statements · 1 reference database · Subject: Negative epigenetic regulation of rRNA expression · Sources: Reactome
- ARID4B participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- BAZ2A participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- CCNH participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- CDK7 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- DNMT1 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- DNMT3B participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- ERCC2 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- ERCC3 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- GTF2H1 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- GTF2H2 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- GTF2H3 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- GTF2H4 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
Show the remaining 62
- GTF2H5 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H2AB1 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H2AC14 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H2AC18; H2AC19 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H2AC20 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H2AC4; H2AC8 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H2AC6 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H2AC7 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H2AJ participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H2AX participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H2AZ2 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H2BC1 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H2BC11 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H2BC12 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H2BC13 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H2BC14 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H2BC15 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H2BC17 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H2BC21 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H2BC26 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H2BC3 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H2BC4; H2BC6; H2BC7; H2BC8; H2BC10 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H2BC9 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H3-3A; H3-3B participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H3C15; H3C14; H3C13 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- HDAC1 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- HDAC2 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- MBD2 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- MNAT1 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- POLR1A participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- POLR1B participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- POLR1C participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- POLR1E participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- POLR1F participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- POLR1G participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- POLR1H participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- POLR2E participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- POLR2F participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- POLR2H participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- POLR2K participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- POLR2L participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- RRP8 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- SAP130 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- SAP18 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- SAP30 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- SAP30BP participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- SAP30L participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- SIN3A participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- SIN3B participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- SIRT1 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- SMARCA5 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- SUDS3 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- SUV39H1 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- TAF1A participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- TAF1B participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- TAF1C participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- TAF1D participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- TBP participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- TTF1 participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only
- UBTF participates in Negative epigenetic regulation of rRNA expressionProteinReactome R-HSA-5250941Inferred only