Pathway
RNA Polymerase I Transcription Initiation
During initiation the double-stranded DNA must be melted and transcription begins. SL1 forms and interacts with UBTF and the rDNA promoter. It is this platform that will recruit active RNA polymerase I to the SL1:phosphorlated UBTF:rDNA promoter complex.
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Mammalian rRNA genes are preceded by a terminator element that is recognized by the SL1 complex. This SL1-modulated acetylation of the basal Pol I transcription machinery has functional consequences suggesting that the reversible acetylation may be one way to regulate rDNA transcription.
REACT:R-HSA-73762Reactome
What the reference databases state
Statements
46 statements
46 statements · 1 reference database · Subject: RNA Polymerase I Transcription Initiation · Sources: Reactome
- CCNH participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- CDK7 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- CHD3 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- CHD4 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- EHMT2 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- ERCC2 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- ERCC3 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- ERCC6 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- GATAD2A participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- GATAD2B participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- GTF2H1 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- GTF2H2 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
Show the remaining 34
- GTF2H3 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- GTF2H4 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- GTF2H5 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- HDAC1 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- HDAC2 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- KAT2A participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- KAT2B participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- MBD3 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- MNAT1 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- MTA1 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- MTA2 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- MTA3 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- POLR1A participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- POLR1B participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- POLR1C participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- POLR1E participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- POLR1F participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- POLR1G participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- POLR1H participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- POLR2E participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- POLR2F participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- POLR2H participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- POLR2K participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- POLR2L participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- RBBP4 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- RBBP7 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- RRN3 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- TAF1A participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- TAF1B participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- TAF1C participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- TAF1D participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- TBP participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- TTF1 participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only
- UBTF participates in RNA Polymerase I Transcription InitiationProteinReactome R-HSA-73762Inferred only