Pathway
Signaling by FGFR
The 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosine kinases (RTKs) designated FGFR1, FGFR2, FGFR3 and FGFR4. These receptors are key regulators of several developmental processes in which cell fate and differentiation to various tissue lineages are determined. Unlike other growth factors, FGFs act in concert with heparin or heparan sulfate proteoglycan (HSPG) to activate FGFRs and to induce the pleiotropic responses that lead to the variety of cellular responses induced by this large family of growth factors. An alternative, FGF-independent, source of FGFR activation originates from the interaction with cell adhesion molecules, typically in the context of interactions on neural cell membranes and is crucial for neuronal survival and development.
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Upon ligand binding, receptor dimers are formed and their intrinsic tyrosine kinase is activated causing phosphorylation of multiple tyrosine residues on the receptors. These then serve as docking sites for the recruitment of SH2 (src homology-2) or PTB (phosphotyrosine binding) domains of adaptors, docking proteins or signaling enzymes. Signaling complexes are assembled and recruited to the active receptors resulting in a cascade of phosphorylation events.
This leads to stimulation of intracellular signaling pathways that control cell proliferation, cell differentiation, cell migration, cell survival and cell shape, depending on the cell type or stage of maturation.
What the reference databases state
Statements
78 statements
78 statements · 1 reference database · Subject: Signaling by FGFR · Sources: Reactome
- ANOS1 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- BRAF participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- CBL participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- ESRP1 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- ESRP2 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FGF1 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FGF10 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FGF16 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FGF18 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FGF19 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FGF2 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FGF20 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
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- FGF22 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FGF23 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FGF3 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FGF4 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FGF6 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FGF7 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FGF9 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FGFBP1 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FGFBP2 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FGFBP3 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FGFR4 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FGFRL1 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FLRT1 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FLRT2 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FLRT3 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FRS2 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- FRS3 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- GAB1 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- GALNT3 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- GIPC1 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- GTF2F1 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- GTF2F2 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- HNRNPA1 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- HNRNPF participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- HNRNPH1 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- HNRNPM participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- HRAS participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- KLB participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- MAPK1 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- MAPK3 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- MKNK1 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- NCBP1 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- NCBP2 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- NRAS participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- PIK3CA participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- PIK3R1 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- PLCG1 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- POLR2A participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- POLR2B participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- POLR2C participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- POLR2D participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- POLR2E participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- POLR2F participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- POLR2G participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- POLR2H participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- POLR2I participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- POLR2J participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- POLR2K participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- POLR2L participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- PPP2CA participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- PPP2CB participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- PPP2R1A participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- PTBP1 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- PTPN11 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- RBFOX2 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- RPS27A participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- SOS1 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- SPRED1 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- SPRED2 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- SPRY2 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- TGFBR3 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- TIA1 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- TIAL1 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- UBA52 participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- UBB participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only
- UBC participates in Signaling by FGFRProteinReactome R-HSA-190236Inferred only