Pathway
mRNA 3'-end processing
The 3' ends of eukaryotic mRNAs are generated by posttranscriptional processing of an extended primary transcript. For almost all RNAs, 3'-end processing consists of two steps: (i) the mRNA is first cleaved at a particular phosphodiester bond downstream of the coding sequence, (ii) the upstream fragment then receives a poly(A) tail of approximately 250 adenylate residues, whereas the downstream fragment is degraded. The two partial reactions are coupled so that reaction intermediates are usually undetectable. While 3' processing can be studied as an isolated event in vitro, it appears to be connected to transcription, splicing, and transcription termination in vivo.
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The only known exception to the rule of cleavage followed by polyadenylation are the major histone mRNAs, which are cleaved but not polyadenylated.
REACT:R-HSA-72187Reactome
What the reference databases state
Statements
151 statements
151 statements · 1 reference database · Subject: mRNA 3'-end processing · Sources: Reactome
- ALYREF participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- CASC3 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- CCAR1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- CDC40 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- CHERP participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- CHTOP participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- CLP1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- CPSF1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- CPSF2 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- CPSF3 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- CPSF4 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- CPSF7 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
Show the remaining 139
- CSTF1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- CSTF2 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- CSTF2T participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- CSTF3 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- DDX39A participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- DDX39B participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- DDX42 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- DDX46 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- DDX5 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- DHX15 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- DHX38 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- DHX9 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- DNAJC8 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- EIF4A3 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- FIP1L1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- FUS participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- FYTTD1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- GTF2F1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- GTF2F2 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- HNRNPA1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- HNRNPA2B1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- HNRNPA3 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- HNRNPC participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- HNRNPD participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- HNRNPF participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- HNRNPH1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- HNRNPH2 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- HNRNPK participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- HNRNPL participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- HNRNPM participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- HNRNPR participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- HNRNPU participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- HTATSF1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- LUZP4 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- MAGOH participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- MAGOHB participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- NCBP1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- NCBP2 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- NUDT21 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- PABPN1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- PAPOLA participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- PAPOLG participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- PCBP1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- PCBP2 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- PCF11 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- PHF5A participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- POLDIP3 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- POLR2A participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- POLR2B participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- POLR2C participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- POLR2D participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- POLR2E participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- POLR2F participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- POLR2G participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- POLR2H participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- POLR2I participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- POLR2J participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- POLR2K participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- POLR2L participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- PPP1CA participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- PPP1CB participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- PPP1R10 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- PPP1R8 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- PRPF40A participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- PTBP1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- PUF60 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- RBBP6 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- RBM10 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- RBM17 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- RBM25 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- RBM39 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- RBM5 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- RBM8A participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- RBMX participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- RNPS1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- RPS27A participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SARNP participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SF3A1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SF3A2 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SF3A3 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SF3B1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SF3B2 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SF3B3 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SF3B4 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SF3B5 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SF3B6 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SLU7 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SMNDC1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SNRNP70 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SNRPA participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SNRPA1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SNRPB participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SNRPB2 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SNRPC participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SNRPD1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SNRPD2 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SNRPD3 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SNRPE participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SNRPF participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SNRPG participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SNRPN participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SRRM1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SRRM2 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SRRT participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SRSF1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SRSF10 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SRSF11 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SRSF12 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SRSF2 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SRSF3 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SRSF4 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SRSF5 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SRSF6 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SRSF7 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SRSF8 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SRSF9 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SUGP1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- SYMPK participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- TCERG1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- THOC1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- THOC2 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- THOC3 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- THOC5 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- THOC6 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- THOC7 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- TRA2B participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- TUT1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- U2AF1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- U2AF1L4 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- U2AF2 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- U2SURP participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- UBA52 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- UBB participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- UBC participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- UPF3B participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- WDR33 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- XRN2 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- YBX1 participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only
- ZC3H11A participates in mRNA 3'-end processingProteinReactome R-HSA-72187Inferred only