ERBIN

Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion. Acts as a mediator of keratinocyte differentiation by sequestering SHOC2 away from ERK-activating RAS complexes..

Function from UniProtKB (Q96RT1), read 2026-09-23. CC BY 4.0.