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Proteins/UNIPROT:O75688
Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB..
Function from UniProtKB (O75688), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
58 statements
58 statements · 5 reference databases · Subject: PPM1B · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways
2 reactions
4 names
Resolves to: PPM1B
O-phospho-L-threonyl-[protein]+waterL-threonyl-[protein]+hydrogenphosphate
Catalysed by PPP6C or CTDSP2 or PPEF1 or PPEF2 or CTDSPL or PPM1D or PPM1G or PHLPP1 or CDC14B or PPM1B or DUSP14 or EPM2A and 59 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47004CC BY 4.0Reference data