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Proteins/UNIPROT:Q9Y5J5
p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor..
Function from UniProtKB (Q9Y5J5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
27 statements
27 statements · 2 reference databases · Subject: PHLDA3 · Sources: gene ontology, Hetionet
3 names
Resolves to: PHLDA3