Proteins/UNIPROT:Q9Y5Y5

PEX16

ProteinUNIPROT:Q9Y5Y5

Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3..

Function from UniProtKB (Q9Y5Y5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

4 rows

peroxisome biogenesis disorder has a germline basis in PEX16DiseaseGenCC HGNC:8857|MONDO:0019234Inferred only
peroxisome biogenesis disorder 8A (Zellweger) has a germline basis in PEX16DiseaseGenCC HGNC:8857|MONDO:0013942Inferred only
peroxisome biogenesis disorder 8B has a germline basis in PEX16DiseaseGenCC HGNC:8857|MONDO:0013943Inferred only
Zellweger spectrum disorders has a germline basis in PEX16DiseaseGenCC HGNC:8857|MONDO:0019609Inferred only

Statements

25 statements

25 statements · 3 reference databases · Subject: PEX16 · Sources: Hetionet, Reactome, WikiPathways

Order

PEX19 interacts with PEX16ProteinHetionet hetionet:interacts:5824-9409Inferred only
PEX16 participates in 11p11 2 copy number variation syndrome PathwayWikiPathways WP5348Inferred only
PEX16 participates in Class I peroxisomal membrane protein importPathwayReactome R-HSA-9603798Inferred only
PEX16 participates in Ether lipid biosynthesisPathwayWikiPathways WP5275Inferred only
PEX16 participates in Protein localizationPathwayReactome R-HSA-9609507Inferred only
AR increases the expression of PEX16ProteinHetionet hetionet:regulates:367-9409Inferred only
ATR increases the expression of PEX16ProteinHetionet hetionet:regulates:545-9409Inferred only
CASC3 increases the expression of PEX16ProteinHetionet hetionet:regulates:22794-9409Inferred only
COPS2 increases the expression of PEX16ProteinHetionet hetionet:regulates:9318-9409Inferred only
COQ8A increases the expression of PEX16ProteinHetionet hetionet:regulates:56997-9409Inferred only
FGFR2 increases the expression of PEX16ProteinHetionet hetionet:regulates:2263-9409Inferred only
HMGCS1 increases the expression of PEX16ProteinHetionet hetionet:regulates:3157-9409Inferred only

Show the remaining 13

IQGAP1 increases the expression of PEX16ProteinHetionet hetionet:regulates:8826-9409Inferred only
KMT2A increases the expression of PEX16ProteinHetionet hetionet:regulates:4297-9409Inferred only
NFKBIA increases the expression of PEX16ProteinHetionet hetionet:regulates:4792-9409Inferred only
NPRL2 increases the expression of PEX16ProteinHetionet hetionet:regulates:10641-9409Inferred only
NSDHL decreases the expression of PEX16ProteinHetionet hetionet:regulates:50814-9409Inferred only
PPIA increases the expression of PEX16ProteinHetionet hetionet:regulates:5478-9409Inferred only
PPIE increases the expression of PEX16ProteinHetionet hetionet:regulates:10450-9409Inferred only
RAF1 increases the expression of PEX16ProteinHetionet hetionet:regulates:5894-9409Inferred only
RBBP6 decreases the expression of PEX16ProteinHetionet hetionet:regulates:5930-9409Inferred only
RXYLT1 increases the expression of PEX16ProteinHetionet hetionet:regulates:10329-9409Inferred only
TBXA2R decreases the expression of PEX16ProteinHetionet hetionet:regulates:6915-9409Inferred only
WRN increases the expression of PEX16ProteinHetionet hetionet:regulates:7486-9409Inferred only
ZFX increases the expression of PEX16ProteinHetionet hetionet:regulates:7543-9409Inferred only

Other names

2 names

Resolves to: PEX16

Also called: Peroxin-16Peroxisomal biogenesis factor 16

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