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Proteins/UNIPROT:Q15628
Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity)..
Function from UniProtKB (Q15628), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
112 statements
112 statements · 4 reference databases · Subject: TRADD · Sources: gene ontology, Hetionet, Reactome, WikiPathways
2 names
Resolves to: TRADD