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Proteins/UNIPROT:Q92581
Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A6 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Responsible for alkalizing and maintaining the endosomal pH, and consequently in, e.g., endosome maturation and trafficking of recycling endosomal cargo. Plays a critical role during neurodevelopment by regulating synaptic development and plasticity (By similarity). Implicated in the maintenance of cell polarity in a manner that is dependent on its ability to modulate intravesicular pH. Regulates intracellular pH in some specialized cells, osteoclasts and stereocilia where this transporter localizes to the plasma membrane (By similarity)..
Function from UniProtKB (Q92581), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · transported by
2 compounds
2 compounds.
0 reported routes2 assembled routes
1 row
87 statements
87 statements · 6 reference databases · Subject: SLC9A6 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Reactome, Rhea
2 reactions
sodium(1+)+hydronsodium(1+)+hydron
Transported by SLC9A1 or SLC9A3 or SLC9A5 or SLC9A4 or SLC9B2 or SLC9A9 or SLC9A6 or SLC9A7 or SLC9A2 or SLC9A8
Reaction pageReversibleBalanced
Rhea RHEA:29419CC BY 4.0Reference data
5 names
Resolves to: SLC9A6
Reaction pageLeft to rightBalanced
Rhea RHEA:29467CC BY 4.0Reference data