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Proteins/UNIPROT:Q9H3R1
Essential enzyme that catalyzes the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has no deacetylase activity but high sulfotransferase activity. Plays a crucial role in the differentiation of colonic progenitor cells (By similarity)..
Function from UniProtKB (Q9H3R1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
13 statements
13 statements · 4 reference databases · Subject: NDST4 · Sources: Hetionet, Human-GEM, Reactome, WikiPathways
3 reactions
2 names
Resolves to: NDST4
4water+MAM02095g+43'-phospho-5'-adenylyl sulfate4acetate+4proton+MAM02082g+4adenosine 3',5'-bismonophosphate
Catalysed by NDST1 or NDST4 or NDST3 or NDST2
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.8Golgi apparatus
Human-GEM MAR07216CC BY 4.0Reference data
alpha-D-glucosaminyl-[heparan sulfate](n)+3'-phosphoadenylyl sulfateN-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NDST3 or NDST1 or NDST2 or NDST4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:21980CC BY 4.0Reference data