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Proteins/UNIPROT:Q9H2P9
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis..
Function from UniProtKB (Q9H2P9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
17 statements
17 statements · 2 reference databases · Subject: DPH5 · Sources: Hetionet, Reactome
2 reactions
proton+MAM02700c+CHEBI:16680MAM02699c+S-adenosyl-L-methionine
Catalysed by DPH5
Reaction pageReversibleBalance undeterminableEC 2.1.1.98cytosol
Human-GEM MAR09549CC BY 4.0Reference data
2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2]+4S-adenosyl-L-methioninediphthine methyl ester-[translation elongation factor 2]+4S-adenosyl-L-homocysteine+3hydron
Catalysed by
1 name
Resolves to: DPH5
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:42652CC BY 4.0Reference data