Pathway
HS-GAG biosynthesis
Heparan sulfate (HS) and heparin (sometimes collectively called HS-GAG) chains consist of the variably sulfated repeating disaccharide units heparan (Ido-GlcNAc) or heparosan (GlcA-GlcNAc). Heparin is exclusively made in mast cells whereas HS is made by virtually every type of cell in the body. As the chain length increases, the polysaccharides can undergo modifications such as epimerisation of glucuronic acid to iduronic acid and deacetylation and sulfation of GlcNAc to form sulfated glucosamine.
REACT:R-HSA-2022928Reactome
What the reference databases state
Statements
32 statements
32 statements · 1 reference database · Subject: HS-GAG biosynthesis · Sources: Reactome
- AGRN participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- EXT1 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- EXT2 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- EXTL2 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- EXTL3 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- GLCE participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- GPC1 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- GPC2 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- GPC3 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- GPC4 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- GPC5 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- HS2ST1 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
Show the remaining 20
- HS3ST1 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- HS3ST2 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- HS3ST3A1 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- HS3ST3B1 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- HS3ST4 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- HS3ST5 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- HS3ST6 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- HS6ST1 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- HS6ST2 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- HS6ST3 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- HSPG2 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- NDST1 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- NDST2 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- NDST3 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- NDST4 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- SDC1 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- SDC2 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- SDC3 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- SDC4 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only
- SLC35D2 participates in HS-GAG biosynthesisProteinReactome R-HSA-2022928Inferred only