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Proteins/UNIPROT:P52848
[Isoform 1]: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan..
[Isoform 3]: Lacks both N-deacetylase and N-sulfotransferase activities. Acts as a dominant negative on isoform 1, likely by changing the composition of enzyme complexes responsible for elongation and modification of heparan sulfates..
Function from UniProtKB (P52848), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
27 statements
27 statements · 5 reference databases · Subject: NDST1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, WikiPathways
5 reactions
9 names
Resolves to: NDST1
3,3'-diiodo-L-thyronine+3'-phospho-5'-adenylyl sulfate3,3'-diiodo-L-thyronine sulfate+proton+adenosine 3',5'-bismonophosphate
Catalysed by NDST1 or UST or CHST10 or SULT4A1 or CHST7 or HS2ST1 or CHST9 or GAL3ST2 or NDST3 or SULT1B1 or HS6ST3 or GAL3ST4 and 2 more alternatives
Reaction pageLeft to rightBalancedEC 2.8.2.-cytosol
Human-GEM MAR06829CC BY 4.0Reference data
4water+MAM02095g+43'-phospho-5'-adenylyl sulfate4acetate+4proton+MAM02082g+4adenosine 3',5'-bismonophosphate
Catalysed by NDST1 or NDST4 or NDST3 or NDST2
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.8Golgi apparatus
Human-GEM MAR07216CC BY 4.0Reference data
alpha-D-glucosaminyl-[heparan sulfate](n)+3'-phosphoadenylyl sulfateN-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)+adenosine 3',5'-bisphosphate+2hydron
Catalysed by NDST3 or NDST1 or NDST2 or NDST4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:21980CC BY 4.0Reference data
N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)+wateralpha-D-glucosaminyl-[heparan sulfate](n)+acetate
Catalysed by NDST1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:70587CC BY 4.0Reference data