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Proteins/UNIPROT:Q13162
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation..
Function from UniProtKB (Q13162), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
204 statements
204 statements · 6 reference databases · Subject: PRDX4 · Sources: Bgee, Hetionet, Human Protein Atlas, Reactome, Rhea, WikiPathways
1 reaction
a hydroperoxide+[thioredoxin]-dithiolan alcohol+[thioredoxin]-disulfide+water
Catalysed by PRDX5 or PRDX3 or PRDX2 or PRDX1 or PRDX4
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:62620CC BY 4.0Reference data
7 names
Resolves to: PRDX4