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Proteins/UNIPROT:P54855
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens). Displays glucuronidation activity toward several classes of xenobiotic substrates, including phenolic compounds (eugenol, 4-nitrophenol, 4-hydroxybiphenyl) and phenylpropanoids (naringenin, coumarins). Catalyzes the glucuronidation of monoterpenoid alcohols such as borneol, menthol and isomenthol, a class of natural compounds used in essential oils (By similarity)..
Function from UniProtKB (P54855), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
33 statements
33 statements · 6 reference databases · Subject: UGT2B15 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
48 reactions
6 names
Resolves to: UGT2B15
Human-GEM MAR02461CC BY 4.0Reference data
MAM01220r+UDP-alpha-D-glucuronateMAM01240r+proton+UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum
Human-GEM MAR02462CC BY 4.0Reference data
MAM00274c+proton+UDPMAM01220c+UDP-alpha-D-glucuronate
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction pageReversibleBalancedEC 2.4.1.17cytosol
Human-GEM MAR02463CC BY 4.0Reference data
MAM01220r+UDP-alpha-D-glucuronateMAM00274r+proton+UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum
Human-GEM MAR02464CC BY 4.0Reference data
MAM00314c+UDP-alpha-D-glucuronateMAM00323c+proton+UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction pageReversibleBalancedEC 2.4.1.17cytosol
Human-GEM MAR02467CC BY 4.0Reference data
MAM00314r+UDP-alpha-D-glucuronateMAM00323r+proton+UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum
Human-GEM MAR02468CC BY 4.0Reference data
MAM00314c+UDP-alpha-D-glucuronateMAM00327c+proton+UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction pageReversibleBalancedEC 2.4.1.17cytosol
Human-GEM MAR02469CC BY 4.0Reference data
MAM00314r+UDP-alpha-D-glucuronateMAM00327r+proton+UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum
Human-GEM MAR02470CC BY 4.0Reference data
UDP-alpha-D-glucuronate+MAM03337rproton+UDP+MAM03341r
Catalysed by UGT2B10 or UGT2B28 or UGT2B4 or UGT1A6 or UGT2B7 or UGT2B15 or UGT2B17 or UGT2B11 or UGT1A5 or UGT1A9 or UGT1A1 or UGT1A10 and 3 more alternatives
Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum
Human-GEM MAR02617CC BY 4.0Reference data
UDP-alpha-D-glucuronate+MAM03338rproton+UDP+MAM03342r
Catalysed by UGT2B10 or UGT2B28 or UGT2B4 or UGT1A6 or UGT2B7 or UGT2B15 or UGT2B17 or UGT2B11 or UGT1A5 or UGT1A9 or UGT1A1 or UGT1A10 and 3 more alternatives
Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum
Human-GEM MAR02627CC BY 4.0Reference data
UDP-alpha-D-glucuronate+MAM03339rproton+UDP+MAM03343r
Catalysed by UGT2B10 or UGT2B28 or UGT2B4 or UGT1A6 or UGT2B7 or UGT2B15 or UGT2B17 or UGT2B11 or UGT1A5 or UGT1A9 or UGT1A1 or UGT1A10 and 3 more alternatives
Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum
Human-GEM MAR02631CC BY 4.0Reference data
UDP-alpha-D-glucuronate+MAM03340rproton+UDP+MAM03344r
Catalysed by UGT2B10 or UGT2B28 or UGT2B4 or UGT1A6 or UGT2B7 or UGT2B15 or UGT2B17 or UGT2B11 or UGT1A5 or UGT1A9 or UGT1A1 or UGT1A10 and 3 more alternatives
Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum
Human-GEM MAR02637CC BY 4.0Reference data