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Proteins/UNIPROT:Q6UWM9

UGT2A3

Protein·UNIPROT:Q6UWM9UDP-glucuronosyltransferase 2A3

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UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions by conjugating glucuronic acid to lipophilic substrates, thereby increasing their water solubility and facilitating excretion. Catalyzes the glucuronidation of the bile acids hyodeoxycholic acid, deoxycholic acid, chenodeoxycholic acid, and ursodeoxycholic acid..

Function from UniProtKB (Q6UWM9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

42 statements

42 statements · 7 reference databases · Subject: UGT2A3 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways

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UGT2A3 covaries with CFAP61ProteinHetionet hetionet:covaries:26074-79799Inferred only
UGT2A3 is expressed in colonAnatomyHuman Protein Atlas ENSG00000135220Inferred only
UGT2A3 is expressed in duodenumAnatomyHuman Protein Atlas ENSG00000135220Inferred only
UGT2A3 is expressed in duodenumAnatomyBgee ENSG00000135220Inferred only
UGT2A3 is expressed in gallbladderAnatomyBgee ENSG00000135220Inferred only
UGT2A3 is expressed in rectumAnatomyHuman Protein Atlas ENSG00000135220Inferred only
UGT2A3 is expressed in Small intestineAnatomyHuman Protein Atlas ENSG00000135220Inferred only
UGT2A3 is expressed in vermiform appendixAnatomyHuman Protein Atlas ENSG00000135220Inferred only
17beta-estradiol is metabolised by UGT2A3CompoundHuman-GEM MAR07648Inferred only
3,3'-diiodo-L-thyronine is metabolised by UGT2A3CompoundHuman-GEM MAR06828Inferred only
3,3'-diiodo-L-thyronine is metabolised by UGT2A3CompoundHuman-GEM MAR06830Inferred only
3,3',5-triiodo-L-thyronine is metabolised by UGT2A3CompoundHuman-GEM MAR06799Inferred only

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3,3',5-triiodo-L-thyronine is metabolised by UGT2A3CompoundHuman-GEM MAR06798Inferred only
all-trans-4-hydroxyretinoate is metabolised by UGT2A3CompoundHuman-GEM MAR06705Inferred only
all-trans-4-hydroxyretinoate is metabolised by UGT2A3CompoundHuman-GEM MAR06704Inferred only
bilirubin IXalpha is metabolised by UGT2A3CompoundHuman-GEM MAR04766Inferred only
chenodeoxycholate is metabolised by UGT2A3CompoundHuman-GEM MAR12179Inferred only
chenodeoxycholate is metabolised by UGT2A3CompoundHuman-GEM MAR12175Inferred only
chenodeoxycholate is metabolised by UGT2A3CompoundHuman-GEM MAR12178Inferred only
chenodeoxycholate is metabolised by UGT2A3CompoundHuman-GEM MAR12174Inferred only
glucuronate acceptor is metabolised by UGT2A3CompoundRhea RHEA:21032Inferred only
hyocholate is metabolised by UGT2A3CompoundHuman-GEM MAR12246Inferred only
hyocholate is metabolised by UGT2A3CompoundHuman-GEM MAR12247Inferred only
hyodeoxycholate is metabolised by UGT2A3CompoundRhea RHEA:52964Inferred only
hyodeoxycholate is metabolised by UGT2A3CompoundHuman-GEM MAR12254Inferred only
hyodeoxycholate is metabolised by UGT2A3CompoundHuman-GEM MAR12255Inferred only
hyodeoxycholate is metabolised by UGT2A3CompoundHuman-GEM MAR12258Inferred only
hyodeoxycholate is metabolised by UGT2A3CompoundHuman-GEM MAR12259Inferred only
L-thyroxine is metabolised by UGT2A3CompoundHuman-GEM MAR06800Inferred only
L-thyroxine is metabolised by UGT2A3CompoundHuman-GEM MAR06801Inferred only
lithocholic acid is metabolised by UGT2A3CompoundHuman-GEM MAR12272Inferred only
lithocholic acid is metabolised by UGT2A3CompoundHuman-GEM MAR12276Inferred only
lithocholic acid is metabolised by UGT2A3CompoundHuman-GEM MAR12277Inferred only
lithocholic acid is metabolised by UGT2A3CompoundHuman-GEM MAR12273Inferred only
UGT2A3 participates in Aspirin ADMEPathwayReactome R-HSA-9749641Inferred only
UGT2A3 participates in Biological oxidationsPathwayReactome R-HSA-211859Inferred only
UGT2A3 participates in Drug ADMEPathwayReactome R-HSA-9748784Inferred only
UGT2A3 participates in GlucuronidationPathwayWikiPathways WP698Inferred only
UGT2A3 participates in GlucuronidationPathwayReactome R-HSA-156588Inferred only
UGT2A3 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
UGT2A3 participates in Metapathway biotransformation Phase I and IIPathwayWikiPathways WP702Inferred only
UGT2A3 participates in Phase II - Conjugation of compoundsPathwayReactome R-HSA-156580Inferred only

Reactions

53 reactions

MAM01220c+UDP-alpha-D-glucuronateMAM01240c+proton+UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction page

Other names

1 name

Resolves to: UGT2A3

Also called: UDPGT 2A3

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Reversible

Balanced

EC 2.4.1.17

cytosol

Human-GEM MAR02461CC BY 4.0Reference data

MAM01220r+UDP-alpha-D-glucuronateMAM01240r+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02462CC BY 4.0Reference data

MAM00274c+proton+UDPMAM01220c+UDP-alpha-D-glucuronate

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageReversibleBalancedEC 2.4.1.17cytosol

Human-GEM MAR02463CC BY 4.0Reference data

MAM01220r+UDP-alpha-D-glucuronateMAM00274r+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02464CC BY 4.0Reference data

MAM00314c+UDP-alpha-D-glucuronateMAM00323c+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageReversibleBalancedEC 2.4.1.17cytosol

Human-GEM MAR02467CC BY 4.0Reference data

MAM00314r+UDP-alpha-D-glucuronateMAM00323r+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02468CC BY 4.0Reference data

MAM00314c+UDP-alpha-D-glucuronateMAM00327c+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageReversibleBalancedEC 2.4.1.17cytosol

Human-GEM MAR02469CC BY 4.0Reference data

MAM00314r+UDP-alpha-D-glucuronateMAM00327r+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02470CC BY 4.0Reference data

bilirubin IXalpha+2UDP-alpha-D-glucuronateMAM01397r+2UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR04766CC BY 4.0Reference data

MAM01923c+UDP-alpha-D-glucuronateMAM01924c+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17cytosol

Human-GEM MAR06490CC BY 4.0Reference data

MAM00766c+UDP-alpha-D-glucuronateMAM01321c+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17cytosol

Human-GEM MAR06495CC BY 4.0Reference data

MAM01231c+UDP-alpha-D-glucuronateall-trans-retinoyl-1-O-(beta-D-glucuronate)+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17cytosol

Human-GEM MAR06666CC BY 4.0Reference data

Show the remaining 41