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Proteins/UNIPROT:P51580
Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor. TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified..
Function from UniProtKB (P51580), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
60 statements
60 statements · 7 reference databases · Subject: TPMT · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
3 reactions
6-methylthiopurine+proton+CHEBI:16680S-adenosyl-L-methionine+MAM02989c
Catalysed by TPMT
Reaction pageReversibleBalancedEC 2.1.1.67cytosol
Human-GEM MAR09504CC BY 4.0Reference data
mercaptopurine+S-adenosyl-L-methionine6-methylthiopurine+S-adenosyl-L-homocysteine+hydron
Catalysed by TPMT
1 name
Resolves to: TPMT
Rhea RHEA:12609CC BY 4.0Reference data
6-thioguanine+S-adenosyl-L-methionine6-methylthioguanine+S-adenosyl-L-homocysteine+hydron
Catalysed by TPMT
Reaction pageDirection not assertedBalanced
Rhea RHEA:56580CC BY 4.0Reference data