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Proteins/UNIPROT:Q6NUN0
Acyl-CoA synthetase that catalyzes the ATP-dependent activation of fatty acids to their corresponding acyl-CoA thioesters, the first committed step in fatty acid metabolism (By similarity). Negatively regulates lipid accumulation via inhibition of FABP4-PPARgamma signaling..
Function from UniProtKB (Q6NUN0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
29 statements
29 statements · 6 reference databases · Subject: ACSM5 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt
9 reactions
ATP+butyric acid+CHEBI:1146900AMP+butanoyl-CoA+diphosphate(3-)
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00156CC BY 4.0Reference data
ATP+
2 names
Resolves to: ACSM5
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00165CC BY 4.0Reference data
ATP+CHEBI:1146900+MAM02120cAMP+CHEBI:27540+diphosphate(3-)
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00168CC BY 4.0Reference data
ATP+CHEBI:1146900+heptanoateAMP+MAM02107c+diphosphate(3-)
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00171CC BY 4.0Reference data
ATP+CHEBI:1146900+octanoateAMP+octanoyl-CoA+diphosphate(3-)
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00174CC BY 4.0Reference data
ATP+CHEBI:1146900+nonanoateAMP+MAM02616c+diphosphate(3-)
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00177CC BY 4.0Reference data
ATP+CHEBI:1146900+decanoateAMP+decanoyl-CoA+diphosphate(3-)
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00180CC BY 4.0Reference data
ATP+CHEBI:1146900+MAM03117cAMP+diphosphate(3-)+undecanoyl-CoA
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00184CC BY 4.0Reference data
a medium-chain fatty acid+ATP(4-)+coenzyme A(4-)a medium-chain fatty acyl-CoA+AMP+diphosphate(3-)
Catalysed by ACSL3 or ACSM4 or ACSM1 or ACSM2A or ACSM3 or ACSM2B or ACSM5 or ACSM6 or ACSF2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:48340CC BY 4.0Reference data