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Proteins/UNIPROT:Q9HAS3
Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Transports uridine. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine..
Function from UniProtKB (Q9HAS3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
64 statements
64 statements · 4 reference databases · Subject: SLC28A3 · Sources: Hetionet, Human-GEM, Reactome, Rhea
28 reactions
adenosine+sodium(1+)adenosine+sodium(1+)
Transported by SLC28A2 or SLC28A1 or SLC28A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04845CC BY 4.0Reference data
4 names
Resolves to: SLC28A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05129CC BY 4.0Reference data
2'-deoxyuridine+sodium(1+)2'-deoxyuridine+sodium(1+)
Transported by SLC28A2 or SLC28A1 or SLC28A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06352CC BY 4.0Reference data
inosine+sodium(1+)inosine+sodium(1+)
Transported by SLC28A2 or SLC28A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06353CC BY 4.0Reference data
2'-deoxyinosine+sodium(1+)2'-deoxyinosine+sodium(1+)
Transported by SLC28A2 or SLC28A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06354CC BY 4.0Reference data
adenosine+2sodium(1+)adenosine+2sodium(1+)
Transported by SLC28A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06355CC BY 4.0Reference data
2sodium(1+)+thymidine2sodium(1+)+thymidine
Transported by SLC28A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06356CC BY 4.0Reference data
inosine+2sodium(1+)inosine+2sodium(1+)
Transported by SLC28A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06357CC BY 4.0Reference data
2sodium(1+)+uridine2sodium(1+)+uridine
Transported by SLC28A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06358CC BY 4.0Reference data
2'-deoxyguanosine+2sodium(1+)2'-deoxyguanosine+2sodium(1+)
Transported by SLC28A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06359CC BY 4.0Reference data
guanosine+2sodium(1+)guanosine+2sodium(1+)
Transported by SLC28A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06360CC BY 4.0Reference data
cytidine+2sodium(1+)cytidine+2sodium(1+)
Transported by SLC28A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06361CC BY 4.0Reference data