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Proteins/UNIPROT:Q14542
Bidirectional uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis. Functions as a Na(+)-independent, passive transporter. Involved in the transport of nucleosides such as inosine, adenosine, uridine, thymidine, cytidine and guanosine. Also able to transport purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil). Also mediates nicotinamide uptake supporting homeostasis and modulating its biological activities. Can also transport urate. Involved in nucleoside transport at basolateral membrane of kidney cells, allowing liver absorption of nucleoside metabolites. Mediates apical nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis-barrier. Mediates both the influx and efflux of hypoxanthine in skeletal muscle microvascular endothelial cells to control the amount of intracellular hypoxanthine available for xanthine oxidase-mediated ROS production (By similarity)..
[Isoform 3]: Non functional nucleoside transporter protein for adenosine or thymidine transport. Does not express on cell membrane..
Function from UniProtKB (Q14542), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
67 statements
67 statements · 5 reference databases · Subject: SLC29A2 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea
33 reactions
Transported by SLC29A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR04847CC BY 4.0Reference data
Transported by SLC29A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR04848CC BY 4.0Reference data
Transported by
11 names
Resolves to: SLC29A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR04882CC BY 4.0Reference data
MAM02997cMAM02997e
Transported by SLC29A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR04980CC BY 4.0Reference data
Transported by SLC29A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR04985CC BY 4.0Reference data
2'-deoxyguanosine2'-deoxyguanosine
Transported by SLC29A1 or SLC29A2
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR04997CC BY 4.0Reference data
Transported by SLC29A1 or SLC29A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05003CC BY 4.0Reference data
2'-deoxyuridine2'-deoxyuridine
Transported by SLC29A1 or SLC29A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05008CC BY 4.0Reference data
Transported by SLC29A1 or SLC29A4 or SLC29A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05032CC BY 4.0Reference data
Transported by SLC29A1 or SLC29A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05034CC BY 4.0Reference data
Transported by SLC29A1 or SLC29A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05035CC BY 4.0Reference data
Transported by SLC29A1 or SLC29A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05037CC BY 4.0Reference data