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Proteins/UNIPROT:O15244
Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics. Functions as a Na(+)-independent, bidirectional uniporter. Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient. However, may also engage electroneutral cation exchange when saturating concentrations of cation substrates are reached (By similarity). Predominantly expressed at the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds by hepatic and renal clearance from the blood flow. Implicated in monoamine neurotransmitters uptake such as histamine, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, serotonin and tyramine, thereby supporting a physiological role in the central nervous system by regulating interstitial concentrations of neurotransmitters. Also capable of transporting dopaminergic neuromodulators cyclo(his-pro), salsolinol and N-methyl-salsolinol, thereby involved in the maintenance of dopaminergic cell integrity in the central nervous system. Mediates the bidirectional transport of acetylcholine (ACh) at the apical membrane of ciliated cell in airway epithelium, thereby playing a role in luminal release of ACh from bronchial epithelium. Also transports guanidine and endogenous monoamines such as vitamin B1/thiamine, creatinine and N-1-methylnicotinamide (NMN). Mediates the uptake and efflux of choline. Mediates the bidirectional transport of polyamine agmatine and the uptake of polyamines putrescine and spermidine. Able to transport non-amine endogenous compounds such as prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha). Also involved in the uptake of xenobiotic 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable)..
[Isoform 2]: In contrast with isoform 1, not able to transport guanidine, creatinine, cimetidine and metformin..
Function from UniProtKB (O15244), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 3 · transported by
3 compounds
3 compounds.
0 reported routes3 assembled routes
52 statements
52 statements · 5 reference databases · Subject: SLC22A2 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
38 reactions
3 names
Resolves to: SLC22A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR04999CC BY 4.0Reference data
(R)-noradrenaline(R)-noradrenaline
Transported by SLC22A2 or SLC22A3 or SLC29A4 or SLC22A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06241CC BY 4.0Reference data
Transported by SLC22A2 or SLC22A3 or SLC29A4 or SLC22A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06243CC BY 4.0Reference data
Transported by SLC22A2 or SLC22A3 or SLC22A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06245CC BY 4.0Reference data
prostaglandin E2prostaglandin E2
Transported by SLC22A2 or SLC22A3 or SLCO2A1 or SLC22A1 or SLCO3A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06246CC BY 4.0Reference data
prostaglandin F2alphaprostaglandin F2alpha
Transported by SLC22A2 or SLCO2A1 or SLC22A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06247CC BY 4.0Reference data
Transported by SLC22A2 or SLC22A3 or SLC29A4 or SLC22A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06732CC BY 4.0Reference data
MAM01647cMAM01647e
Transported by SLC22A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR08031CC BY 4.0Reference data
Transported by SLC22A2 or SLC29A4 or SLC22A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR09192CC BY 4.0Reference data
Transported by SLC22A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR09193CC BY 4.0Reference data
Transported by SLC22A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR09195CC BY 4.0Reference data