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Proteins/UNIPROT:O75751
Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics. Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient. Functions as a Na(+)- and Cl(-)-independent, bidirectional uniporter. Implicated in monoamine neurotransmitters uptake such as dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine, serotonin and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the brain. Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with low efficiency. May be involved in the uptake and disposition of cationic compounds by renal clearance from the blood flow. May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable). Mediates the transport of polyamine spermidine and putrescine (By similarity). Mediates the bidirectional transport of polyamine agmatine. Also transports guanidine. Mediates the transport of choline. May mediate intracellular transport of organic cations due to its localization on endomembranes, thereby contributing to amine metabolism and intracellular signaling (By similarity)..
Function from UniProtKB (O75751), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
32 statements
32 statements · 6 reference databases · Subject: SLC22A3 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
22 reactions
Transported by SLC22A2 or SLC22A3 or SLC22A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR04999CC BY 4.0Reference data
(R)-noradrenaline(R)-noradrenaline
Transported by SLC22A2 or SLC22A3 or SLC29A4 or SLC22A1
Reaction pageReversibleBalancedcytosol, extracellular space
6 names
Resolves to: SLC22A3
Transported by SLC22A2 or SLC22A3 or SLC29A4 or SLC22A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06243CC BY 4.0Reference data
Transported by SLC22A2 or SLC22A3 or SLC22A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06245CC BY 4.0Reference data
prostaglandin E2prostaglandin E2
Transported by SLC22A2 or SLC22A3 or SLCO2A1 or SLC22A1 or SLCO3A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06246CC BY 4.0Reference data
Transported by SLC22A2 or SLC22A3 or SLC29A4 or SLC22A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06732CC BY 4.0Reference data
MAM02035cMAM02035e
Transported by SLC22A3 or SLC22A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR09581CC BY 4.0Reference data
N(tau)-methylhistamineN(tau)-methylhistamine
Transported by SLC22A3
Reaction pageReversibleBalancedEC 7.6.2.2cytosol, extracellular space
Human-GEM MAR11782CC BY 4.0Reference data
MAM03099cMAM03099e
Transported by SLC22A2 or SLC22A3 or SLC22A1
Reaction pageReversibleBalancedEC 7.6.2.2cytosol, extracellular space
Human-GEM MAR11806CC BY 4.0Reference data
trimethylenediaminetrimethylenediamine
Transported by SLC22A2 or SLC22A3 or SLC22A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR11807CC BY 4.0Reference data
Transported by SLC35F4 or SLC22A2 or SLC22A1 or SLC22A3 or SLC35G4 or CHRNA7 or CLDN2 or SLC25A48 or SLC35F2 or SLC35F3 or SLC35F5 or FLVCR2 and 2 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:32751CC BY 4.0Reference data
Transported by SLC22A2 or SLC22A1 or SLC22A3 or SLC45A4 or SLC22A16 or PANX1
Reaction pageDirection not assertedBalanced
Rhea RHEA:35039CC BY 4.0Reference data