O-tetradecanoyl-(R)-carnitine

Three steps

• cholineReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 3 morecytosol, nucleus

• CHEBI:15380Reach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 4 morecytosol, mitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 5 morecytosol, mitochondrial matrixOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. Production of Tiglylcarnitine

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 4 morecytosolOne of 2 routes

• isobutyryl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 5 morecytosol, mitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 3 morecytosol, mitochondrial matrix

• isovaleryl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 5 morecytosol, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 12 routes

• CHEBI:15519Reach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. propanoyl-CoA C-acyltransferase

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 5 morecytosol, peroxisomeOne of 2 routes

• oleoyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 5 morecytosolOne of 12 routes

• phenylacetyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. Phenylacetate:CoA ligase

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 2 morecytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 5 morecytosolOne of 43 routes

• CHEBI:15650Reach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 34 morecytosolOne of 2 routes

• CHEBI:15727Reach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 3 morecytosol

• CHEBI:15746Reach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 4 morecytosolOne of 2 routes

• hexadecanoic acidReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. fatty-acyl-CoA synthase (N-C16:0CoA)
  3. Palmitoyl-CoA hydrolase

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 2 morecytosolOne of 2 routes

• 1-acylglycerone 3-phosphateReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:glycerone-phosphate O-acyltransferase

  Catalysed by CPT2, GNPATcytosol

• phosphatidylethanolamineReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase

  Catalysed by CPT2, LPCAT4, LPCAT3, LPCAT2 and 2 morecytosol

• 1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by CPT2, LPCAT4, LPCAT3, LPCAT2 and 1 morecytosol

• hexadecan-1-olReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. fatty-acyl-CoA synthase (N-C16:0CoA)
  3. formate dehydrogenase (palmitoyl-CoA)

  Catalysed by CPT2, FAR1, FAR2cytosol, peroxisome

• 11-cis-retinyl hexadecanoateReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. fatty-acyl-CoA synthase (N-C16:0CoA)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by CPT2, DGAT1, LRAT, AWAT1 and 2 morecytosol

• 11-cis-retinolReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 7 morecytosol

• phosphatidic acidReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. acyl-CoA pool formation and breakdown
  3. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

  Catalysed by CPT2, AGPAT2, LCLAT1, MBOAT1 and 6 morecytosol, mitochondrial matrixOne of 7 routes

• oxaloacetateReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. ATP citrate lyase (citrate)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 3 morecytosol

• 9-hydroxytetradecanoateReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. tetradecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 9-hydroxytetradecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 3 morecytosol

• 10-hydroxytetradecanoateReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. tetradecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxytetradecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 3 morecytosol

• 12-hydroxytetradecanoateReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. tetradecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 12-hydroxytetradecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 3 morecytosol

• 11-hydroxytetradecanoateReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. tetradecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 11-hydroxytetradecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 3 morecytosol

• 1-acyl-sn-glycerol 3-phosphateReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. glycerol-3-phosphate 1-O-acyltransferase (myristoyl-CoA)
  3. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation

  Catalysed by CPT2, GPAT3, GPAT2, GPAT4 and 1 morecytosolOne of 9 routes

• a cholesterol esterReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + cholesterol = a cholesterol ester + CoA

  Catalysed by CPT2, SOAT2, SOAT1cytosol

• itaconateReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate

  Catalysed by CPT2, SLC22A8, SUGCTinner side of the membrane, outer side of the membrane

• anilineReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 4 morecytosol

• CHEBI:17312Reach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 2 morecytosolOne of 2 routes

• 3-hydroxy-3-methylglutarateReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate

  Catalysed by CPT2, SLC22A8, SUGCTinner side of the membrane, outer side of the membrane

• 1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase

  Catalysed by CPT2, LPCAT4, LPCAT3, LPCAT2 and 1 morecytosol

• L-cysteineReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 3 morecytosol, mitochondrial matrix

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 5 morecytosol, mitochondrial matrix

• CHEBI:17724Reach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)
  3. Trimethylaminoacetate:L-homosysteine S-methyltransferase

  Catalysed by CPT2, SLC22A5, BHMT, BHMT2inner side of the membrane, outer side of the membrane, cytosol

• urateReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. urate(in) + glutarate(out) = urate(out) + glutarate(in)

  Catalysed by CPT2, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• a 1,2-diacyl-sn-glycerolReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. acyl-CoA pool formation and breakdown
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA

  Catalysed by CPT2, MOGAT2, AWAT2, MOGAT1cytosol

• a triacylglycerolReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. acyl-CoA pool formation and breakdown
  3. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

  Catalysed by CPT2, DGAT1, MOGAT2, MOGAT3 and 2 morecytosol

• CHEBI:17927Reach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 2 morecytosol

• dodecanoateReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Fatty Acid Beta Oxidation (C14->C12), Mitochondrial
  3. Lauroyl-CoA hydrolase

  Catalysed by CPT2, HADHA, ACADVL, HADHB and 4 moremitochondrial matrix, cytosolOne of 2 routes

• 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)Reach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) = 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by CPT2, SLC22A8, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• (5Z)-dodecenoyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 5 morecytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 10 morecytosolOne of 6 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 5 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 5 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 5 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
  2. Myristoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by CPT2, ACOT7, BAAT, THEM4 and 5 morecytosol, mitochondrial matrixOne of 2 routes