dodecanedioyl-CoA

Three steps

• S-methyl-5'-thioadenosineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. S-adenosylmethioninamine:spermidine 3-aminopropyltransferase

  Catalysed by ACOT8, SAT1, SAT2, SRM and 1 moreperoxisome, cytosolOne of 2 routes

• 5-aminolevulinic acidReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by ACOT8, GLYAT, GLYATL2, GLYATL1 and 3 moreperoxisome, mitochondrial matrixOne of 2 routes

• all-trans-retinyl hexadecanoateReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)

  Catalysed by ACOT8, DGAT1, LRAT, AWAT1 and 3 moreperoxisome, cytosol

• Ala-tRNA(Ala)Reach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by ACOT8, AARS1peroxisome, mitochondrial matrix, cytosol

• CHEBI:17769Reach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. spermidine:(acceptor) oxidoreductase

  Catalysed by ACOT8, SAT1, SAT2peroxisome, cytosol

• a 1,2-diacyl-sn-glycerolReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA

  Catalysed by ACOT8, ASAH1, ACER2, ACER1 and 4 moreperoxisome, Golgi apparatus

• a triacylglycerolReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

  Catalysed by ACOT8, ASAH1, ACER2, ACER1 and 6 moreperoxisome, Golgi apparatus, cytosol

• CHEBI:17895Reach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and tyrosine (cytosol to extracellular)

  Catalysed by ACOT8, GLYAT, GLYATL2, GLYATL1 and 1 moreperoxisome, mitochondrial matrix, extracellular space, cytosolOne of 19 routes

• butanoateReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. Butanoate:CoA ligase (AMP-forming)
  3. butanoyl-CoA + H2O = butanoate + CoA + H(+)

  Catalysed by ACOT8, ACSM4, ACSM1, ACSM2A and 8 moreperoxisome, cytosol

• CHEBI:18019Reach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and lysine (cytosol to extracellular)

  Catalysed by ACOT8, GLYAT, GLYATL2, GLYATL1 and 1 moreperoxisome, mitochondrial matrix, extracellular space, cytosolOne of 10 routes

• L-glutamineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glutamine and glycine (cytosol to extracellular)

  Catalysed by ACOT8, GLYAT, GLYATL2, GLYATL1 and 1 moreperoxisome, mitochondrial matrix, extracellular space, cytosolOne of 29 routes

• spermine monoaldehydeReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. diamine N-acetyltransferase (N1-acetylspermine)
  3. primary-amine oxidase (spermine)

  Catalysed by ACOT8, SAT1, SAT2, AOC2 and 2 moreperoxisome, cytosolOne of 3 routes

• CHEBI:18095Reach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Transport of Hydroxy-Proline

  Catalysed by ACOT8, SLC1A4peroxisome, mitochondrial matrix, extracellular space, cytosol

• O-octanoyl-(R)-carnitineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. Carnitine O-Palmitoyltransferase
  3. solute carrier (L-carnitine)

  Catalysed by ACOT8, CPT1A, CPT1C, CPT1B and 1 moreperoxisome, cytosol, mitochondrial matrixOne of 11 routes

• CHEBI:18132Reach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. Acetyl-CoA:choline O-acetyltransferase
  3. ATP:choline phosphotransferase

  Catalysed by ACOT8, CHAT, CHKA, CHKBperoxisome, nucleus, cytosol

• dodecanoateReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. Lauroyl-CoA hydrolase

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 9 moreperoxisome, cytosolOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by ACOT8, GLYAT, GLYATL2, GLYATL1 and 1 moreperoxisome, mitochondrial matrix, cytosol

• N-(4-aminobutyl)-3-aminopropanalReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. primary-amine oxidase (spermidine)

  Catalysed by ACOT8, SAT1, SAT2, AOC2 and 2 moreperoxisome, cytosolOne of 3 routes

• (2E,5Z,8Z,11Z,14Z,17Z)-eicosahexaenoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (EPA)
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z,17Z)-eicosahexaenoyl-CoA + H2O2

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosol

• ophthalmateReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by ACOT8, GLYAT, GLYATL2, GLYATL1 and 1 moreperoxisome, mitochondrial matrix

• S-methylmercury-L-cysteineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by ACOT8, NAGS, SLC7A8peroxisome, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-aminoisobutanoateReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by ACOT8, SLC7A10peroxisome, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• 11-cis-retinyl esterReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. 11-cis-retinol + a fatty acyl-CoA = 11-cis-retinyl ester + CoA

  Catalysed by ACOT8, DGAT1, LRAT, AWAT1 and 2 moreperoxisome, cytosol

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. ATP citrate lyase (citrate)
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by ACOT8, ACLY, AGXT2peroxisome, cytosol

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by ACOT8, GLYAT, GLYATL2, GLYATL1 and 1 moreperoxisome, mitochondrial matrixOne of 2 routes

• 1-butanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. Butanoate:CoA ligase (AMP-forming)
  3. 2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by ACOT8, ACSM4, ACSM1, ACSM2A and 5 moreperoxisome, cytosol

• 1-octanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. 2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA = 1-octanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by ACOT8, CROT, MOGAT2, MOGAT1peroxisome, mitochondrial matrix

• 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. eicosanoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by ACOT8, GLYAT, GLYATL2, GLYATL1 and 1 moreperoxisome, mitochondrial matrix, cytosolOne of 2 routes

• O-butanoyl-(R)-carnitineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. Butanoate:CoA ligase (AMP-forming)
  3. butanoyl-CoA + (R)-carnitine = O-butanoyl-(R)-carnitine + CoA

  Catalysed by ACOT8, ACSM4, ACSM1, ACSM2A and 4 moreperoxisome, cytosol

• S-disulfanyl-L-cysteineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by ACOT8, NAGS, CARS2peroxisome, mitochondrial matrix

• 3-oxo-(9Z)-eicosenoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)
  3. very-long-chain 3-oxoacyl-CoA synthase ((7Z)-octadecenoyl-CoA)

  Catalysed by ACOT8, CPT1A, CPT1C, CPT1B and 7 moreperoxisome, cytosol

• (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)
  3. (6Z,9Z,12Z)-octadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 8 moreperoxisome, cytosolOne of 2 routes

• (2E,7Z,10Z)-hexadecatrienoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial
  3. (7Z,10Z)-hexadecadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z,10Z)-hexadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by ACOT8, HADHA, ACADVL, HADHB and 2 moreperoxisome, mitochondrial matrix

• (2E,4Z,7Z,10Z,13Z)-hexadecapentaenoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial
  3. Fatty Acid Beta Oxidation (C16:4->C16:5), Mitochondrial

  Catalysed by ACOT8, HADHA, ACADVL, HADHBperoxisome, mitochondrial matrixOne of 4 routes

• (2E,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial
  3. (7Z,10Z,13Z)-hexadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z,10Z,13Z)-hexadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by ACOT8, HADHA, ACADVL, HADHB and 2 moreperoxisome, mitochondrial matrix

• (2E,4Z,7Z)-decatrienoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial
  3. Fatty Acid Beta Oxidation (C10:2->C10:3), Mitochondrial

  Catalysed by ACOT8, ECHS1, ACAA2, HADH and 1 moreperoxisome, mitochondrial matrixOne of 3 routes

• docosanoateReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (behenic acid)
  3. Docosanoyl-CoA hydrolase

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosolOne of 4 routes

• CHEBI:240943Reach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by ACOT8, GLYAT, GLYATL2, GLYATL1peroxisome, mitochondrial matrixOne of 2 routes

• octadecanoateReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. Stearoyl-CoA hydrolase

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 9 moreperoxisome, cytosolOne of 4 routes

• octanoateReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. Octanoyl-CoA hydrolase

  Catalysed by ACOT8, CROT, ACOT7peroxisome, mitochondrial matrix, cytosolOne of 2 routes

• alpha-linolenic acidReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by ACOT8, CPT1A, CPT1C, CPT1Bperoxisome, cytosol, endoplasmic reticulumOne of 2 routes

• phenylacetylglycineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by ACOT8, GLYAT, GLYATL2, GLYATL1peroxisome, mitochondrial matrix, cytosolOne of 6 routes

• decanoateReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. medium-chain acyl-CoA ligase (decanoic acid)
  3. Decanoyl-CoA hydrolase

  Catalysed by ACOT8, ACSM4, ACSM1, ACSM2A and 4 moreperoxisome, cytosolOne of 2 routes

• all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (DHA)
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosolOne of 2 routes

• hexacosan-1-olReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)
  3. hexacosanoyl-CoA + 2 NADPH + 2 H(+) = hexacosan-1-ol + 2 NADP(+) + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• CHEBI:28666Reach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. LTD4 hydrolysis

  Catalysed by ACOT8, ZDHHC11B, NAA10, ESCO2 and 29 moreperoxisome, cytosolOne of 2 routes

• O-decanoyl-(R)-carnitineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. medium-chain acyl-CoA ligase (decanoic acid)
  3. decanoyl-CoA + (R)-carnitine = O-decanoyl-(R)-carnitine + CoA

  Catalysed by ACOT8, ACSM4, ACSM1, ACSM2A and 5 moreperoxisome, cytosol

• pyridoxine 5'-phosphateReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by ACOT8, SCLYperoxisome, mitochondrial matrix, cytosol