1-hexadecanoylglycerone 3-phosphate

Three steps

• (15Z)-tetracosenoateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosol, extracellular spaceOne of 12 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosol, extracellular spaceOne of 14 routes

• (11Z)-eicosenoateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosol, extracellular spaceOne of 12 routes

• cholesteryl hexadecanoateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Palmitate:CoA ligase (AMP-forming)
  3. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosol, endoplasmic reticulumOne of 2 routes

• taurineReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by GNPAT, BAATperoxisome, cytosolOne of 2 routes

• glycineReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by GNPAT, GLYAT, GLYATL2, GLYATL1peroxisome, cytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by GNPAT, ALDH6A1peroxisome, cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by GNPATperoxisome, cytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by GNPAT, ACP2peroxisome, cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by GNPATperoxisome, cytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by GNPAT, ACAA1, MYO5Bperoxisome, cytosolOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Utilized Transport
  3. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)

  Catalysed by GNPAT, SLC33A1, ESCO2, OXSMperoxisome, endoplasmic reticulum, cytosol, mitochondrial matrixOne of 11 routes

• dodecanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. Production of Glutaryl Carnitine

  Catalysed by GNPAT, CPT1A, CPT1C, CPT1Bperoxisome, cytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by GNPAT, SUCLG1, SUCLG2, SUCLA2peroxisome, cytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Palmitate:CoA ligase (AMP-forming)
  3. Fatty Acid Beta Oxidation (C16->C14), Mitochondrial

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 8 moreperoxisome, cytosol, mitochondrial matrixOne of 13 routes

• octanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Palmitate:CoA ligase (AMP-forming)
  3. Beta Oxidation of Long Chain Fatty Acid

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosol, mitochondrial matrixOne of 22 routes

• phytanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. phytanate-CoA ligase

  Catalysed by GNPATperoxisome, cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Palmitate:CoA ligase (AMP-forming)
  3. fatty-acyl-CoA synthase (N-C18:0CoA)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 22 routes

• (R)-2-hydroxyoctadecanoateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. octadecanoate + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O

  Catalysed by GNPAT, FA2Hperoxisome, cytosol

• O-acetyl-(R)-carnitineReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Utilized Transport
  3. Acetyl-CoA:carnitine O-acetyltransferase

  Catalysed by GNPAT, CPT1A, CPT1C, CPT1Bperoxisome, endoplasmic reticulum, cytosolOne of 9 routes

• dihydroxyacetone phosphateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+)
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)
  3. sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)

  Catalysed by DHRS7B, LYPLA2, PNPLA7, PNPLA6 and 2 moreOne of 2 routes

• sphing-4-enineReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by GNPAT, ASAH1, ACER2, ACER1 and 1 moreperoxisome, cytosol, Golgi apparatusOne of 4 routes

• spermidineReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by GNPAT, SAT1, SAT2peroxisome, cytosolOne of 3 routes

• L-methionineReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by GNPAT, NAGSperoxisome, cytosol, mitochondrial matrix

• sphinganine 1-phosphateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. 2 H+[c] + NADH[c] + palmitate[c] = H2O[c] + hexadecanal[c] + NAD+[c]
  3. Sphinganine-1-phosphate pamlmitaldehyde-lyase

  Catalysed by GNPAT, ALDH3B1, ALDH3B2, ALDH3A2 and 1 moreperoxisome, cytosol

• a 1-acyl-sn-glycero-3-phosphateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+)
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)
  3. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA

  Catalysed by DHRS7B, LYPLA2, PNPLA7, PNPLA6 and 4 more

• L-alanineReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by GNPATperoxisome, cytosol, mitochondrial matrix

• a 1-O-alkyl-sn-glycero-3-phosphateReach from here →
  1. 1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid = a 1-acylglycerone 3-phosphate + hexadecanoate
  2. a long chain fatty alcohol + a 1-acylglycerone 3-phosphate = a 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)
  3. a 1-O-alkylglycerone 3-phosphate + NADPH + H(+) = a 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)

  Catalysed by AGPS, DHRS7B

• L-asparagineReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by GNPAT, NAGSperoxisome, cytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by GNPAT, NAGSperoxisome, cytosol, mitochondrial matrix

• 3-oxosphinganineReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Palmitate:CoA ligase (AMP-forming)
  3. Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 8 moreperoxisome, cytosolOne of 2 routes

• CDP-glycerolReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+)
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)
  3. CDP-glycerol + H2O = sn-glycerol 3-phosphate + CMP + 2 H(+)

  Catalysed by DHRS7B, LYPLA2, PNPLA7, PNPLA6 and 1 more

• an acyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Palmitate:CoA ligase (AMP-forming)
  3. acyl-CoA pool formation and breakdown

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 3 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by GNPAT, HADHA, ACAA2, HADHBperoxisome, cytosol, mitochondrial matrixOne of 3 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosol, extracellular spaceOne of 12 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by GNPAT, SLC27A2, SLC27A5peroxisome, cytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by GNPAT, SLC27A2, SLC27A5peroxisome, cytosolOne of 4 routes

• a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate)Reach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+)
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)
  3. a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)

  Catalysed by DHRS7B, LYPLA2, PNPLA7, PNPLA6 and 1 more

• decanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by GNPAT, ACSM4, ACSM1, ACSM2A and 3 moreperoxisome, cytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Palmitate:CoA ligase (AMP-forming)
  3. trans-hexadec-2-enoyl-CoA reductase

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol, mitochondrial matrixOne of 9 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Palmitate:CoA ligase (AMP-forming)
  3. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosolOne of 15 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by GNPAT, CPT1A, CPT1Bperoxisome, cytosol

• CHEBI:63544Reach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 7 routes

• 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by AGPS, SLC27A2, ACSL4, ACSL3 and 9 more

• hexacosanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 10 routes