2-oxo-3-sulfanylpropanoate

Three steps

• dTTPReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. pyruvate kinase (dTDP)
  3. DTTP Nucleotidohydrolase

  Catalysed by MPST, TST, PKM, PKLR and 3 morecytosol, extracellular spaceOne of 11 routes

• CHEBI:18095Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of alanine and cysteine (cytosol to extracellular)
  3. Transport of Hydroxy-Proline

  Catalysed by GOT2, GOT1, SLC7A5, SLC1A4cytosol, extracellular spaceOne of 5 routes

• CHEBI:18183Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. L-glutamate:L-cysteine gamma-ligase (ADP-forming)
  3. gamma-glutamylcyclotransferase (gamma-glutamyl-cysteine)

  Catalysed by GOT2, GOT1, GCLC, GCLM and 2 morecytosol

• N-carbamoyl-beta-alanineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by GOT2, GOT1, SLC6A14cytosol, extracellular spaceOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space

• arsenic triglutathioneReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by MPST, TSTD1, AS3MTOne of 3 routes

• 2-phenylethylamineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by GOT2, GOT1, SLC7A5, DDCcytosol, extracellular space

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space

• ophthalmateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space

• S-methylmercury-L-cysteineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and methionine (cytosol to extracellular)
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by GOT2, GOT1, SLC7A5, SLC7A8cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-(alpha-Hydroxypropyl)thiamine diphosphateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. branched chain keto acid dehydrogenase E1 (2-oxobutyrate)

  Catalysed by MPST, TST, AGXT2, BCKDHA and 1 morecytosol, mitochondrial matrix

• 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)Reach from here →
  1. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) = 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by AADAT, SLC22A6, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-aminoisobutanoateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of alanine and cysteine (cytosol to extracellular)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by GOT2, GOT1, SLC7A5, SLC7A10cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-isoleucineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. D-serine = pyruvate + NH4(+)
  3. D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D-serine(out)

  Catalysed by MPST, TST, SRR, SLC7A10cytosol, inner side of the membrane, outer side of the membrane

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by MPST, TSTD1, MGST3

• 3-carboxy-4-methyl-5-propyl-2-furanpropanoateReach from here →
  1. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
  2. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)
  3. 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)

  Catalysed by AADAT, SLC22A8, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• L-sepiapterinReach from here →
  1. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
  2. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)
  3. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)

  Catalysed by AADAT, SLC22A8, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by MPST, TSTD1, GPX1, GPX4

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by MPST, TSTD1, GPX1, GPX4

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by MPST, TSTD1, GPX1, GPX4

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by MPST, TSTD1, GPX1, GPX4

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by MPST, TSTD1, GPX4

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular spaceOne of 4 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular spaceOne of 2 routes

• (5Z)-dodecenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by GOT2, GOT1, NAGS, HADHA and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (S)-lactoyl-AMPReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + ATP + H(+) = (S)-lactoyl-AMP + diphosphate

  Catalysed by MPST, TST, LDHA, LDHB and 5 morecytosol

• (S)-lactoyl-CoAReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + ATP + CoA = (S)-lactoyl-CoA + AMP + diphosphate

  Catalysed by MPST, TST, LDHA, LDHB and 4 morecytosol

• N-acetylneuraminate 9-phosphateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. pyruvate kinase (dTDP)
  3. N-acetylneuraminate synthase

  Catalysed by MPST, TST, PKM, PKLR and 1 morecytosol

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by GOT2, GOT1, NAGS, HADHA and 2 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by GOT2, GOT1, NAGS, HADHA and 2 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by GOT2, GOT1, NAGS, ECHS1 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by GOT2, GOT1, NAGS, ECHS1 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by MPST, TSTD1, GSTP1

• CHEBI:240943Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 4 morecytosol, extracellular space, mitochondrial matrixOne of 3 routes

• hypochlorous acidReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. Peroxidase

  Catalysed by GOT2, GOT1, SLC6A14, LPOcytosol, extracellular spaceOne of 4 routes

• potassium atomReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by GOT2, GOT1, SLC6A14, SLC12A2 and 1 morecytosol, extracellular spaceOne of 2 routes

• folic acidReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. Folate Transport by Oats

  Catalysed by MPST, TST, SLC22A8, SLC22A7cytosol, extracellular spaceOne of 2 routes

• phenylacetylglycineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular spaceOne of 3 routes

• CHEBI:27540Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by GOT2, GOT1, NAGS, ACSM4 and 5 morecytosol, mitochondrial matrixOne of 6 routes

• selenomethionineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. Selenomethionine methanethiol-lyase (deaminating)

  Catalysed by MPST, TST, AGXT2, CTHcytosol

• CHEBI:27760Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. Selenocystathionine Lysteine-lyase (deaminating)

  Catalysed by MPST, TST, AGXT2, CTHcytosol

• elaidic acidReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 5 routes

• 5-hydroxytryptophanReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by GOT2, GOT1, SLC7A5, TPH1 and 1 morecytosol, extracellular spaceOne of 2 routes

• 5(S)-HETEReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by GOT2, GOT1, GPX5, GPX1 and 7 morecytosolOne of 2 routes

• 2-oxopentanoateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
  3. 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate

  Catalysed by MPST, TST, AGXT2cytosol

• CHEBI:28666Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. LTD4 hydrolysis

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 1 morecytosol, extracellular spaceOne of 3 routes

• CHEBI:28701Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by GOT2, GOT1, NAGS, ACAA1 and 2 morecytosol, mitochondrial matrix, peroxisomeOne of 7 routes

• 17alpha-hydroxypregnenoloneReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space, endoplasmic reticulum