7,8-dihydrofolate

Three steps

• glyoxylic acidReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by DHFR, DHFR2, SHMT1, DAOcytosol, peroxisome

• oxalic acidReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. Folate Transport by Oats
  3. transport of oxalate and sulfate (cytosol to extracellular)

  Catalysed by DHFR, DHFR2, SLC22A8, SLC22A7 and 1 morecytosol, extracellular space

• L-isoleucineReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and isoleucine (cytosol to extracellular)

  Catalysed by DHFR, DHFR2, SHMT1, SLC7A5cytosol, extracellular spaceOne of 4 routes

• CHEBI:17203Reach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and proline (cytosol to extracellular)

  Catalysed by DHFR, DHFR2, SHMT1, SLC7A5 and 1 morecytosol, extracellular spaceOne of 2 routes

• sulfiteReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. Folate Transport by Oats
  3. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)

  Catalysed by DHFR, DHFR2, SLC22A8, SLC22A7 and 2 morecytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-aminolevulinic acidReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by DHFR, DHFR2, SHMT1, ALAS1 and 2 morecytosol, mitochondrial matrix

• L-cysteineReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of cysteine and glycine (cytosol to extracellular)

  Catalysed by DHFR, DHFR2, SHMT1, SLC3A2 and 2 morecytosol, extracellular spaceOne of 4 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. Folate Transport by Oats
  3. Steryl-Sulfatase

  Catalysed by DHFR, DHFR2, SLC22A8, SLC22A7 and 1 morecytosol, extracellular space, Golgi apparatusOne of 2 routes

• CHEBI:17895Reach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and tyrosine (cytosol to extracellular)

  Catalysed by DHFR, DHFR2, SHMT1, SLC7A5cytosol, extracellular spaceOne of 4 routes

• fumaric acidReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. Folate Transport by Oats
  3. transport of fumarate and sulfate (cytosol to mitochondria)

  Catalysed by DHFR, DHFR2, SLC22A8, SLC22A7 and 1 morecytosol, extracellular space, mitochondrial matrixOne of 2 routes

• CHEBI:18019Reach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and lysine (cytosol to extracellular)

  Catalysed by DHFR, DHFR2, SHMT1, SLC7A6cytosol, extracellular spaceOne of 2 routes

• L-glutamineReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glutamine and glycine (cytosol to extracellular)

  Catalysed by DHFR, DHFR2, SHMT1, SLC7A5cytosol, extracellular spaceOne of 4 routes

• N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. Formate:tetrahydrofolate ligase (ADP-forming)
  3. 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase

  Catalysed by DHFR, DHFR2, MTHFD1, GARTcytosol

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by DHFR, DHFR2, SHMT1, GARTcytosol

• CHEBI:18381Reach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. Formate:tetrahydrofolate ligase (ADP-forming)
  3. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)

  Catalysed by DHFR, DHFR2, MTHFD1, ATICcytosolOne of 2 routes

• (6S)-5-methyl-5,6,7,8-tetrahydrofolateReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
  3. 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) + (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) + (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in)

  Catalysed by DHFR, DHFR2, ATIC, SLC19A1cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• ophthalmateReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by DHFR, DHFR2, SHMT1, GSScytosol

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by DHFR, DHFR2, SHMT1, AGXT2cytosol

• CHEBI:240943Reach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by DHFR, DHFR2, SHMT1, GLYAT and 2 morecytosol, mitochondrial matrix

• phenylacetylglycineReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by DHFR, DHFR2, SHMT1, GLYATcytosolOne of 3 routes

• selenomethionineReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. histamine N-methyltransferase (SAM)
  3. Methionine Synthase

  Catalysed by DHFR, DHFR2, HNMTcytosol, nucleusOne of 2 routes

• CHEBI:28666Reach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. LTD4 hydrolysis

  Catalysed by DHFR, DHFR2, SHMT1cytosol

• a dicarboxylateReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. Folate Transport by Oats
  3. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by DHFR, DHFR2, SLC22A8, SLC22A7 and 2 morecytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• Gly-tRNA(Gly)Reach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by DHFR, DHFR2, SHMT1, GARS1cytosol

• chlorine(.)Reach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of chloride and glycine (cytosol to extracellular)

  Catalysed by DHFR, DHFR2, SHMT1, SLC6A9 and 1 morecytosol, extracellular spaceOne of 4 routes

• glycocholateReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by DHFR, DHFR2, SHMT1, BAATcytosol, peroxisomeOne of 3 routes

• D-aspartateReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. Folate Transport by Oats
  3. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by DHFR, DHFR2, SLC22A8, SLC22A7 and 2 morecytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-aspartateReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. Folate Transport by Oats
  3. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)

  Catalysed by DHFR, DHFR2, SLC22A8, SLC22A7 and 2 morecytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• oxalateReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. Folate Transport by Oats
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by DHFR, DHFR2, SLC22A8, SLC22A7 and 5 morecytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• maleateReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. Folate Transport by Oats
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by DHFR, DHFR2, SLC22A8, SLC22A7 and 2 morecytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• malonic acidReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. Folate Transport by Oats
  3. transport of malonate and sulfate (cytosol to mitochondria)

  Catalysed by DHFR, DHFR2, SLC22A8, SLC22A7 and 1 morecytosol, extracellular space, mitochondrial matrixOne of 2 routes

• (2R,3R)-tartrateReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. Folate Transport by Oats
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by DHFR, DHFR2, SLC22A8, SLC22A7 and 2 morecytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. Folate Transport by Oats
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by DHFR, DHFR2, SLC22A8, SLC22A7 and 2 morecytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. Folate Transport by Oats
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by DHFR, DHFR2, SLC22A8, SLC22A7 and 2 morecytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. Folate Transport by Oats
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by DHFR, DHFR2, SLC22A8, SLC22A7 and 2 morecytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• thiosulfateReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. Folate Transport by Oats
  3. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)

  Catalysed by DHFR, DHFR2, SLC22A8, SLC22A7 and 4 morecytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-aminolevulinateReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by DHFR, DHFR2, SHMT1, ALAS1 and 1 morecytosol

• glycochenodeoxycholateReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by DHFR, DHFR2, SHMT1, BAATcytosol

• glycochenodeoxycholic acidReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by DHFR, DHFR2, SHMT1, BAATcytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by DHFR, DHFR2, SHMT1, AADATcytosolOne of 11 routes

• glycolithocholic acidReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by DHFR, DHFR2, SHMT1, BAATcytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by DHFR, DHFR2, SHMT1, GCATcytosol, mitochondrial matrix

• L-ornithineReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. L-Arginine:glycine amidinotransferase

  Catalysed by DHFR, DHFR2, SHMT1, GATMcytosolOne of 5 routes

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by DHFR, DHFR2, SHMT1, GLDC and 1 morecytosol, mitochondrial matrix

• sarcosineReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by DHFR, DHFR2, SHMT1, PIPOXcytosolOne of 2 routes

• (6R)-5,10-methenyltetrahydrofolateReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase

  Catalysed by DHFR, DHFR2, SHMT1, MTHFD2 and 1 morecytosol, mitochondrial matrixOne of 11 routes

• an N-acylglycineReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by DHFR, DHFR2, SHMT1, GLYATL3 and 2 morecytosol

• guanidinoacetateReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. L-Arginine:glycine amidinotransferase

  Catalysed by DHFR, DHFR2, SHMT1, GATMcytosolOne of 2 routes

• L-methionineReach from here →
  1. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and methionine (cytosol to extracellular)

  Catalysed by DHFR, DHFR2, SHMT1, SLC7A5cytosol, extracellular spaceOne of 6 routes

• N-sulfo-D-glucosamineReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. Folate Transport by Oats
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by DHFR, DHFR2, SLC22A8, SLC22A7 and 1 morecytosol, extracellular space