(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

Three steps

• glycochenodeoxycholateReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by GPX1, GPX2, GPX4, GSR and 1 moreinner side of the membrane, outer side of the membrane

• taurocholateReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. solute carrier organic anion transporter (GSH)

  Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 10 morecytosol, extracellular spaceOne of 3 routes

• glycolithocholic acidReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of glycolithocholate and GSH (cytosol to extracellular)

  Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 10 morecytosol, extracellular spaceOne of 2 routes

• 25-hydroxycholesterolReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O

  Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 2 more

• all-trans-4-oxoretinolReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. cytochrome P450 (retinol)

  Catalysed by TBXAS1, PTGS2, PTGIS, RETSAT and 1 morecytosol

• phosphoenolpyruvic acidReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. (R)-malate + A = oxaloacetate + AH2
  3. GTP:oxaloacetate carboxy-lyase (adding GTP

  Catalysed by TBXAS1, PTGS2, PTGIS, D2HGDH and 1 morecytosolOne of 2 routes

• 13-cis-retinolReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. retinol binding protein (retinol)

  Catalysed by TBXAS1, PTGS2, PTGIS, RETSAT and 2 morecytosolOne of 2 routes

• tert-butanolReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by GPX1, GPX2, GPX4, GSR and 2 more

• L-ornithineReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and ornithine (cytosol to extracellular)

  Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 moreextracellular space, cytosolOne of 2 routes

• gamma-Glu-AlaReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. gamma-glutamyltransferase (alanine)

  Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 14 morecytosol, extracellular space

• all-trans-13,14-dihydroretinolReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 2 moreOne of 2 routes

• 3,3',5-triiodo-L-thyronineReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 3 moreOne of 3 routes

• 3,3',5'-triiodo-L-thyronineReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 3 more

• glycineReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and glycine (cytosol to extracellular)

  Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 3 moreextracellular space, cytosolOne of 4 routes

• prostaglandin E1Reach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin E1 (cytosol to extracellular)

  Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 9 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin I2Reach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin I2 (cytosol to extracellular)

  Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 9 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin F2alphaReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 9 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin H2Reach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

  Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 2 moreOne of 4 routes

• prostaglandin D2Reach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin D2 (cytosol to extracellular)

  Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 9 morecytosol, extracellular spaceOne of 2 routes

• sarcosineReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by TBXAS1, PTGS2, PTGIS, KDM1A and 2 more

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. (6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)

  Catalysed by TBXAS1, PTGS2, PTGIS, MTO1 and 2 more

• leukotriene A4Reach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and leukotriene A4 (cytosol to extracellular)

  Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 9 morecytosol, extracellular spaceOne of 2 routes

• (R)-S-lactoylglutathioneReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 10 morecytosolOne of 3 routes

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. L-Cysteine:2-oxoglutarate aminotransferase

  Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 2 morecytosolOne of 3 routes

• S-formylglutathioneReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by TBXAS1, PTGS2, PTGIS, KDM1A and 7 morecytosolOne of 3 routes

• L-methionineReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 2 moreOne of 10 routes

• L-tryptophanReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and tryptophan (cytosol to extracellular)

  Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 moreextracellular space, cytosolOne of 4 routes

• L-alanineReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)

  Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 2 moreOne of 18 routes

• leukotriene C4Reach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. leukotriene C4 synthase (GSH)

  Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 9 morecytosolOne of 5 routes

• L-asparagineReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of asparagine and cysteine (cytosol to extracellular)

  Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 moreextracellular space, cytosolOne of 4 routes

• L-phenylalanineReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and phenylalanine (cytosol to extracellular)

  Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 moreextracellular space, cytosolOne of 6 routes

• gamma-L-glutamyl-L-cysteineReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 2 morecytosolOne of 2 routes

• taurolithocholate 3-sulfateReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and sulfotaurolithocholate (cytosol to extracellular)

  Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 10 morecytosol, extracellular spaceOne of 2 routes

• 5-oxo-L-prolineReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. glutathione = L-cysteinylglycine + 5-oxo-L-proline

  Catalysed by GPX1, GPX2, GPX4, GSR and 2 more

• histamineReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and histamine (cytosol to extracellular)

  Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 10 morecytosol, extracellular spaceOne of 2 routes

• L-thyroxineReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and thyroxine (cytosol to extracellular)

  Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 10 morecytosol, extracellular spaceOne of 2 routes

• S-sulfanyl-L-cysteineReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 more

• phosphoenolpyruvateReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. (R)-malate + A = oxaloacetate + AH2
  3. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2

  Catalysed by TBXAS1, PTGS2, PTGIS, D2HGDH and 2 more

• S-sulfanylglutathioneReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 9 morecytosol, mitochondrial matrixOne of 6 routes

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 morecytosolOne of 4 routes

• dopamineReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of dopamine and GSH (cytosol to extracellular)

  Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 10 morecytosol, extracellular spaceOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)

  Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 10 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin E2Reach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin E2 (cytosol to extracellular)

  Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 10 morecytosol, extracellular spaceOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. L-Cysteine:oxygen oxidoreductase

  Catalysed by TBXAS1, PTGS2, PTGIS, MOCOS and 1 morecytosolOne of 2 routes

• L-cysteinylglycineReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. glutathione gamma-glutamylaminopeptidase

  Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 14 morecytosolOne of 6 routes

• an all-trans-retinyl esterReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. Lecithin Retinol Acyltransferase

  Catalysed by TBXAS1, PTGS2, PTGIS, RETSAT and 1 morecytosolOne of 4 routes

• ubiquinol-10Reach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10

  Catalysed by GPX1, GPX2, GPX4, GSR and 1 more

• a 2,3-saturated acyl-CoAReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2

  Catalysed by TBXAS1, PTGS2, PTGIS, AIFM1 and 2 moreOne of 2 routes

• all-trans-retinyl 9Z-octadecenoateReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol

  Catalysed by TBXAS1, PTGS2, PTGIS, RETSAT and 2 more

• (R)-noradrenalineReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and noradrenaline (cytosol to extracellular)

  Catalysed by TBXAS1, PTGS2, PTGIS, GPX5 and 10 morecytosol, extracellular spaceOne of 2 routes