CHEBI:28666

Three steps

• N(tau)-methylhistamineReach from here →
  1. transport of LTD4 (cytosol to extracellular)
  2. transport of histamine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:histamine N-tele-methyltransferase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, HNMTextracellular space, cytosolOne of 3 routes

• N-formyl-L-kynurenineReach from here →
  1. membrane dipeptidase (LTD4)
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 = N-formyl-L-kynurenine

  Catalysed by DPEP1, DPEP2, SLC7A5, IDO1 and 2 moreextracellular space, cytosol

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 1 moreextracellular space, peroxisome, endoplasmic reticulumOne of 3 routes

• 5-phospho-beta-D-ribosylamineReach from here →
  1. membrane dipeptidase (LTD4)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. phosphoribosyl pyrophosphate amidotransferase (glutamine)

  Catalysed by DPEP1, DPEP2, SLC7A5, PPATextracellular space, cytosolOne of 2 routes

• D-glucosamine 6-phosphateReach from here →
  1. membrane dipeptidase (LTD4)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate

  Catalysed by DPEP1, DPEP2, SLC7A5, GFPT2 and 1 moreextracellular space, cytosol

• L-methionine (S)-S-oxideReach from here →
  1. membrane dipeptidase (LTD4)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by DPEP1, DPEP2, SLC7A5, MSRAextracellular space, cytosol

• L-methionine (R)-S-oxideReach from here →
  1. membrane dipeptidase (LTD4)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by DPEP1, DPEP2, SLC7A5, MSRB3 and 2 moreextracellular space, cytosol

• 5-amino-2-oxopentanoateReach from here →
  1. membrane dipeptidase (LTD4)
  2. L-Arginine:glycine amidinotransferase
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by DPEP1, DPEP2, GATM, AGXT2extracellular space, cytosolOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 1 moreextracellular space, peroxisome, cytosolOne of 4 routes

• hyodeoxycholateReach from here →
  1. transport of LTD4 (cytosol to extracellular)
  2. transport of lithocholate (cytosol to extracellular)
  3. cytochrome P450 (lithocholate)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, CYP3A4extracellular space, cytosol

• methylamineReach from here →
  1. membrane dipeptidase (LTD4)
  2. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine
  3. N(omega)-methyl-L-arginine + H2O = L-citrulline + methylamine

  Catalysed by DPEP1, DPEP2, AGXT2, DDAH1extracellular space

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. membrane dipeptidase (LTD4)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by DPEP1, DPEP2, SLC3A2, SLC7A5 and 2 moreextracellular space, cytosolOne of 4 routes

• monodehydro-L-ascorbate radicalReach from here →
  1. membrane dipeptidase (LTD4)
  2. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  3. N-(9Z-octadecenoyl)glycine + 2 L-ascorbate + O2 = N-(9Z-octadecenoyl)-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by DPEP1, DPEP2, GLYATL3, GLYATL2 and 1 moreextracellular spaceOne of 14 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. membrane dipeptidase (LTD4)
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

  Catalysed by DPEP1, DPEP2, AADAT, PAHextracellular space

• 4-aminobutanoateReach from here →
  1. membrane dipeptidase (LTD4)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by DPEP1, DPEP2, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosolOne of 4 routes

• 3-iodo-L-tyrosineReach from here →
  1. membrane dipeptidase (LTD4)
  2. transport of glycine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by DPEP1, DPEP2, SLC7A5, TPOextracellular space, cytosolOne of 2 routes

• L-prolineReach from here →
  1. membrane dipeptidase (LTD4)
  2. transport of alanine and glycine (cytosol to extracellular)
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by DPEP1, DPEP2, SLC3A2, SLC7A5 and 2 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. membrane dipeptidase (LTD4)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. L-Cysteine:oxygen oxidoreductase

  Catalysed by DPEP1, DPEP2, SLC3A2, SLC7A5 and 2 moreextracellular space, cytosolOne of 2 routes

• decanoyl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by DPEP1, DPEP2, BAAT, ACSM4 and 5 moreextracellular space, peroxisome, cytosolOne of 8 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by DPEP1, DPEP2, BAAT, CPT1A and 2 moreextracellular space, peroxisome, cytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreextracellular space, peroxisome, cytosolOne of 11 routes

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. membrane dipeptidase (LTD4)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by DPEP1, DPEP2, AADAT, HOGA1extracellular space

• 3-hydroxyisovaleryl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by DPEP1, DPEP2, BAAT, CPT1A and 1 moreextracellular space, peroxisome, cytosol

• chenodeoxycholoyl-CoAReach from here →
  1. transport of LTD4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (chenodiol)
  3. chenodeoxycholate + ATP + CoA = chenodeoxycholoyl-CoA + AMP + diphosphate

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SLC27A5extracellular space, cytosol

• CHEBI:63544Reach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreextracellular space, peroxisome, cytosolOne of 7 routes

• 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of LTD4 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. cytochrome P450 (arachidonate)

  Catalysed by SLCO1B1, CYP4F8extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• ubiquinol-10Reach from here →
  1. membrane dipeptidase (LTD4)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10

  Catalysed by DPEP1, DPEP2, GSS, SQORextracellular space

• hexacosanoyl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreextracellular space, peroxisome, cytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreextracellular space, peroxisome, cytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreextracellular space, peroxisome, cytosolOne of 9 routes

• N(5)-[(Z)-amino(hydroxyimino)methyl]ornithineReach from here →
  1. membrane dipeptidase (LTD4)
  2. transport of arginine and glycine (cytosol to extracellular)
  3. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

  Catalysed by DPEP1, DPEP2, SLC7A6, NOS3 and 2 moreextracellular space, cytosol

• xanthurenateReach from here →
  1. membrane dipeptidase (LTD4)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O

  Catalysed by DPEP1, DPEP2, AADAT, KYAT3extracellular space

• Mo-molybdopterinReach from here →
  1. membrane dipeptidase (LTD4)
  2. transport of alanine and glycine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by DPEP1, DPEP2, SLC3A2, SLC7A5 and 2 moreextracellular space, cytosol

• (R)-adrenalineReach from here →
  1. transport of LTD4 (cytosol to extracellular)
  2. transport of noradrenaline (cytosol to extracellular)
  3. (R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + S-adenosyl-L-homocysteine + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, PNMTextracellular space, cytosol

• (2E)-octadecenoyl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by DPEP1, DPEP2, BAAT, CPT1A and 2 moreextracellular space, peroxisome, cytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreextracellular space, peroxisome, cytosolOne of 8 routes

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. membrane dipeptidase (LTD4)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by DPEP1, DPEP2, AADAT, HOGA1extracellular space

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreextracellular space, peroxisome, cytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreextracellular space, peroxisome, cytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreextracellular space, peroxisome, cytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreextracellular space, peroxisome, cytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreextracellular space, peroxisome, cytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreextracellular space, peroxisome, cytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreextracellular space, peroxisome, cytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreextracellular space, peroxisome, cytosolOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreextracellular space, peroxisome, cytosolOne of 4 routes

• CHEBI:742324Reach from here →
  1. transport of LTD4 (cytosol to extracellular)
  2. transport of dopamine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:catechol O-methyltransferase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, COMT and 1 moreextracellular space, cytosol

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreextracellular space, peroxisome, cytosolOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreextracellular space, peroxisome, cytosolOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreextracellular space, peroxisome, cytosolOne of 7 routes