folic acid

Three steps

• N-carbamoyl-L-aspartateReach from here →
  1. Folate Transport by Oats
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by SLC22A8, SLC22A7, SLC25A14, SLC25A30 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• a phenolReach from here →
  1. Folate Transport by Oats
  2. an aryl sulfate + H2O = a phenol + sulfate + H(+)
  3. an aryl sulfate + H2O = a phenol + sulfate + H(+)

  Catalysed by SLC22A8, SLC22A7, ARSL, ARSF and 4 moreextracellular space, cytosol

• glyoxylateReach from here →
  1. Folate Transport by Oats
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

  Catalysed by SLC22A8, SLC22A7, SLC25A10, CLYBLextracellular space, cytosol, mitochondrial matrix

• L-erythro-7,8-dihydrobiopterinReach from here →
  1. Folate Transport by Oats
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-erythro-7,8-dihydrobiopterin(out) + a dicarboxylate(in) = L-erythro-7,8-dihydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SLC22A8, SLC22A7, SLC25A35, SLC25A34 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (5-hydroxyindol-3-yl)acetaldehydeReach from here →
  1. Folate Transport by Oats
  2. Transport of 5-Hydroxyindoleacetate
  3. (5-hydroxyindol-3-yl)acetaldehyde + NAD(+) + H2O = (5-hydroxyindol-3-yl)acetate + NADH + 2 H(+)

  Catalysed by SLC22A8, SLC22A7, SLC4A1, ALDH9A1extracellular space, cytosol

• taurineReach from here →
  1. Folate Transport by Oats
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by SLC22A8, SLC22A7, SLC26A6, SLC6A6extracellular space, cytosolOne of 2 routes

• glycineReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by DHFR, DHFR2, SHMT1cytosolOne of 7 routes

• (S)-malyl-CoAReach from here →
  1. Folate Transport by Oats
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate

  Catalysed by SLC22A8, SLC22A7, SLC25A10, SUCLG1 and 1 moreextracellular space, cytosol, mitochondrial matrix

• prostaglandin F2alphaReach from here →
  1. Folate Transport by Oats
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)

  Catalysed by SLC22A8, SLC22A7, SLC25A35, SLC25A34 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-formimidoyltetrahydrofolateReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  3. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase

  Catalysed by DHFR, DHFR2, FTCDcytosolOne of 2 routes

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. Folate Transport by Oats
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by SLC22A8, SLC22A7, SLC25A10, ASLextracellular space, cytosol, mitochondrial matrixOne of 4 routes

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. Folate Transport by Oats
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)

  Catalysed by SLC22A8, SLC22A7, SLC25A10, ADSL and 1 moreextracellular space, cytosol, mitochondrial matrixOne of 4 routes

• guanidinoacetateReach from here →
  1. Folate Transport by Oats
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of Guanidinoacetic Acid

  Catalysed by SLC22A8, SLC22A7, SLC26A6extracellular space, cytosol

• 3',5'-cyclic GMPReach from here →
  1. Folate Transport by Oats
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3',5'-cyclic GMP(out) + a dicarboxylate(in) = 3',5'-cyclic GMP(in) + a dicarboxylate(out)

  Catalysed by SLC22A8, SLC22A7, SLC25A35, SLC25A34 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-methionineReach from here →
  1. Folate Transport by Oats
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and methionine (cytosol to extracellular)

  Catalysed by SLC22A8, SLC22A7, SLC26A6, SLC6A14extracellular space, cytosolOne of 4 routes

• adenosine 5'-phosphoramidateReach from here →
  1. Folate Transport by Oats
  2. ATP:sulfate adenylyltransferase
  3. adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'-phosphoramidate + sulfate + 2 H(+)

  Catalysed by SLC22A8, SLC22A7, PAPSS1, PAPSS2 and 1 moreextracellular space, cytosol

• L-tryptophanReach from here →
  1. Folate Transport by Oats
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Tryptophan by Atb0 Transporter

  Catalysed by SLC22A8, SLC22A7, SLC26A6, SLC6A14extracellular space, cytosolOne of 4 routes

• glutathioneReach from here →
  1. Folate Transport by Oats
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by SLC22A8, SLC22A7, SLC25A14, SLC25A30 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• beta-alanineReach from here →
  1. Folate Transport by Oats
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by SLC22A8, SLC22A7, SLC26A6, SLC6A6 and 1 moreextracellular space, cytosolOne of 4 routes

• L-alanineReach from here →
  1. Folate Transport by Oats
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of alanine and chloride (cytosol to extracellular)

  Catalysed by SLC22A8, SLC22A7, SLC26A6, SLC6A14extracellular space, cytosolOne of 3 routes

• L-asparagineReach from here →
  1. Folate Transport by Oats
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Asparagine by Atb0 Transporter

  Catalysed by SLC22A8, SLC22A7, SLC26A6, SLC6A14extracellular space, cytosolOne of 4 routes

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. Folate Transport by Oats
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by SLC22A8, SLC22A7, SLC25A14, SLC25A30 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• L-phenylalanineReach from here →
  1. Folate Transport by Oats
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Phenylalanine by Atb0 Transporter

  Catalysed by SLC22A8, SLC22A7, SLC26A6, SLC6A14extracellular space, cytosolOne of 4 routes

• 3',5'-cyclic AMPReach from here →
  1. Folate Transport by Oats
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3',5'-cyclic AMP(out) + a dicarboxylate(in) = 3',5'-cyclic AMP(in) + a dicarboxylate(out)

  Catalysed by SLC22A8, SLC22A7, SLC25A35, SLC25A34 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• glutathione disulfideReach from here →
  1. Folate Transport by Oats
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by SLC22A8, SLC22A7, SLC25A14, SLC25A30 and 3 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• L-tyrosineReach from here →
  1. Folate Transport by Oats
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)

  Catalysed by SLC22A8, SLC22A7, SLC25A14, SLC25A30 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. Folate Transport by Oats
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by SLC22A8, SLC22A7, SLC25A14, SLC25A30 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. Folate Transport by Oats
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by SLC22A8, SLC22A7, SLC25A10, ADSLextracellular space, cytosol, mitochondrial matrixOne of 4 routes

• kynurenateReach from here →
  1. Folate Transport by Oats
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)

  Catalysed by SLC22A8, SLC22A7, SLC25A35, SLC25A34extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideReach from here →
  1. dihydrofolate:NAD+ oxidoreductase
  2. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  3. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)

  Catalysed by DHFR, DHFR2, ATICcytosol

• D-glucosamineReach from here →
  1. Folate Transport by Oats
  2. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by SLC22A8, SLC22A7, SGSHextracellular space, cytosol

• S-sulfanylglutathioneReach from here →
  1. Folate Transport by Oats
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)

  Catalysed by SLC22A8, SLC22A7, SLC25A14, SLC25A30 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. Folate Transport by Oats
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SLC22A8, SLC22A7, SLC25A35, SLC25A34 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 4-aminobutanoateReach from here →
  1. Folate Transport by Oats
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by SLC22A8, SLC22A7, SLC26A6, SLC6A12extracellular space, cytosolOne of 4 routes

• prostaglandin E2Reach from here →
  1. Folate Transport by Oats
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)

  Catalysed by SLC22A8, SLC22A7, SLC25A35, SLC25A34 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-benzoylglycineReach from here →
  1. Folate Transport by Oats
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)

  Catalysed by SLC22A8, SLC22A7, SLC25A35, SLC25A34 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. Folate Transport by Oats
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)

  Catalysed by SLC22A8, SLC22A7, SLC25A14, SLC25A30 and 2 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 4 routes

• ubiquinol-10Reach from here →
  1. Folate Transport by Oats
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate

  Catalysed by SLC22A8, SLC22A7, SLC25A14, SLC25A30 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• 16alpha-hydroxydehydroepiandrosterone 3-sulfateReach from here →
  1. Folate Transport by Oats
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxydehydroepiandrosterone 3-sulfate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC22A8, SLC22A7, STS, CYP3A7extracellular space, cytosol