potassium atom

Three steps

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by SLC12A2, SLC12A1, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by SLC12A2, SLC12A1, SLC6A14, CARS2extracellular space, cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 5 moreextracellular space, cytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• alpha-linolenic acidReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC12A2, SLC12A1, SLC6A14extracellular space, cytosol, endoplasmic reticulum

• folic acidReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Folate Transport by Oats

  Catalysed by SLC12A2, SLC12A1, SLC26A6, SLC22A8 and 1 moreextracellular space, cytosolOne of 2 routes

• phenylacetylglycineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by SLC12A2, SLC12A1, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosolOne of 3 routes

• CHEBI:27540Reach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 8 moreextracellular space, cytosol, mitochondrial matrixOne of 6 routes

• elaidic acidReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• 5-hydroxytryptophanReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, TPH1 and 1 moreextracellular space, cytosolOne of 2 routes

• 5(S)-HETEReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by SLC6A4, SLCO1A2, SLCO1B3, GPX5 and 8 moreextracellular space, cytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. LTD4 hydrolysis

  Catalysed by SLC12A2, SLC12A1, SLC6A9, SLC6A14extracellular space, cytosolOne of 5 routes

• CHEBI:28701Reach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 5 moreextracellular space, cytosol, mitochondrial matrix, peroxisomeOne of 7 routes

• pyridoxine 5'-phosphateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, SCLYextracellular space, cytosol

• 3-disulfanyl-L-alanineReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)
  3. L-cystine thiocysteine-lyase (deaminating

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• N-acetyl-L-cysteineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, NAGSextracellular space, cytosol, mitochondrial matrix

• a dicarboxylateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by SLC12A2, SLC12A1, SLC26A6, SLC25A35 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• Cys-tRNA(Cys)Reach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, CARS1extracellular space, cytosol

• Phe-tRNA(Phe)Reach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, FARSB and 1 moreextracellular space, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by SLC12A2, SLC12A1, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosol

• Trp-tRNA(Trp)Reach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, WARS1extracellular space, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and isoleucine (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, IARS1extracellular space, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, QARS1extracellular space, cytosol

• hypoioditeReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. iodide + H2O2 = hypoiodite + H2O

  Catalysed by SLC12A2, SLC12A1, SLC26A4, MPO and 1 moreextracellular space, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Asparagine by Atb0 Transporter
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, NARS1extracellular space, cytosol

• phosphocholineReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and choline (cytosol to extracellular)
  3. phosphocholine + H2O = choline + phosphate

  Catalysed by SLC12A2, SLC12A1, SLC5A7, PHOSPHO1extracellular space, cytosolOne of 2 routes

• glycocholateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLC12A2, SLC12A1, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosol, peroxisomeOne of 7 routes

• cholateReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. solute carrier organic anion transporter (cholate)

  Catalysed by SLC6A4, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• hydrogen sulfideReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by SLC12A2, SLC12A1, SLC6A14, CTHextracellular space, cytosolOne of 2 routes

• D-aspartateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by SLC12A2, SLC12A1, SLC26A6, SLC25A14 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• acetateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of acetate and formate (cytosol to extracellular)

  Catalysed by SLC12A2, SLC12A1, SLC26A4, SLC16A4 and 2 moreextracellular space, cytosolOne of 4 routes

• CHEBI:30249Reach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by SLC12A2, SLC12A1, SLC6A14, IDO1 and 2 moreextracellular space, cytosol

• oxalateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by SLC12A2, SLC12A1, SLC26A6, SLC25A14 and 3 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• propionic acidReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of formate and propanoate (cytosol to extracellular)

  Catalysed by SLC12A2, SLC12A1, SLC26A4, SLC16A4 and 2 moreextracellular space, cytosolOne of 2 routes

• citric acidReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SLC12A2, SLC12A1, SLC26A6, SLC25A1extracellular space, cytosol, mitochondrial matrixOne of 5 routes

• butyric acidReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of butyrate and formate (cytosol to extracellular)

  Catalysed by SLC12A2, SLC12A1, SLC26A4, SLC16A4 and 1 moreextracellular space, cytosolOne of 2 routes

• maleateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by SLC12A2, SLC12A1, SLC26A6, SLC25A14 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (9Z)-octadecenoateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC12A2, SLC12A1, SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• (S)-dihydroorotateReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. carbamoyl-phosphate:L-aspartate carbamoyltransferase
  3. (S)-dihydroorotate amidohydrolase

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreextracellular space, cytosolOne of 2 routes

• isocitric acidReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SLC12A2, SLC12A1, SLC26A6, SLC25A1extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreextracellular space, cytosol, mitochondrial matrix

• (2R,3R)-tartrateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by SLC12A2, SLC12A1, SLC26A6, SLC25A14 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by SLC12A2, SLC12A1, SLC26A6, SLC25A14 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by SLC12A2, SLC12A1, SLC26A6, SLC25A14 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by SLC12A2, SLC12A1, SLC26A6, SLC25A14 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes