N(omega),N('omega)-dimethyl-L-arginine

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. phenylacetyl-CoA:glycine N-phenylacetyltransferase

Catalysed by AGXT2, GLYATcytosolOne of 3 routes

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. LTD4 hydrolysis

Catalysed by AGXT2cytosol

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. L-selenocysteine selenide-lyase (L-alanine-forming)

Catalysed by AGXT2, SCLYcytosol

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. glycine:tRNA(Gly) ligase (AMP-forming)

Catalysed by AGXT2, GARS1cytosol

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and chloride (cytosol to extracellular)

Catalysed by AGXT2, SLC6A14extracellular space, cytosolOne of 5 routes

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. bile acid-CoA: amino acid N-acyltransferase

Catalysed by AGXT2, BAATperoxisomeOne of 3 routes

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. oxaloacetate + L-alanine = L-aspartate + pyruvate

Catalysed by AGXT2

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

Catalysed by AGXT2, SLC7A10inner side of the membrane, outer side of the membraneOne of 2 routes

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)

Catalysed by AGXT2, SLC7A10inner side of the membrane, outer side of the membraneOne of 6 routes

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

Catalysed by AGXT2, ALAS1, ALAS2

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

Catalysed by AGXT2, BAAT

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. bile acid-CoA: amino acid N-acyltransferase

Catalysed by AGXT2, BAATperoxisomeOne of 3 routes

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

Catalysed by AGXT2One of 12 routes

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. bile acid-CoA:amino acid N-acyltransferase (glycine)

Catalysed by AGXT2, BAATcytosolOne of 2 routes

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. Acetyl-CoA:glycine C-acetyltransferase

Catalysed by AGXT2, GCATmitochondrial matrix

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and ornithine (cytosol to extracellular)

Catalysed by AGXT2, SLC7A6extracellular space, cytosolOne of 8 routes

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. gamma-glutamyltransferase (alanine)

Catalysed by AGXT2, GGT1, GGT5, GGTLC2 and 3 moreextracellular space, cytosol

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

Catalysed by AGXT2, GLDC, GCSHmitochondrial matrix

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

Catalysed by AGXT2, SLC7A10inner side of the membrane, outer side of the membraneOne of 2 routes

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

Catalysed by AGXT2, PIPOXOne of 2 routes

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

Catalysed by AGXT2, SHMT1, SHMT2

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

Catalysed by AGXT2, GLYATL3, GLYAT, GLYATL2

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. L-Arginine:glycine amidinotransferase

Catalysed by AGXT2, GATMcytosolOne of 2 routes

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

Catalysed by AGXT2, SLC7A10inner side of the membrane, outer side of the membraneOne of 2 routes

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and methionine (cytosol to extracellular)

Catalysed by AGXT2, SLC7A5extracellular space, cytosolOne of 12 routes

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and tryptophan (cytosol to extracellular)

Catalysed by AGXT2, SLC7A5extracellular space, cytosolOne of 9 routes

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

Catalysed by AGXT2, GSS

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)

Catalysed by AGXT2, SLC7A10inner side of the membrane, outer side of the membraneOne of 4 routes

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

Catalysed by AGXT2, KYNU

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

Catalysed by AGXT2, SLC7A10inner side of the membrane, outer side of the membraneOne of 2 routes

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. leukotriene C4 hydrolysis

Catalysed by AGXT2cytosol

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and asparagine (cytosol to extracellular)

Catalysed by AGXT2, SLC7A5extracellular space, cytosolOne of 10 routes

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and phenylalanine (cytosol to extracellular)

Catalysed by AGXT2, SLC7A5extracellular space, cytosolOne of 13 routes

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

Catalysed by AGXT2, KYNU

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

Catalysed by AGXT2, AADAT

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

Catalysed by AGXT2One of 2 routes

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

Catalysed by AGXT2, SLC1A4inner side of the membrane, outer side of the membraneOne of 2 routes

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

Catalysed by AGXT2, GLYATL2One of 2 routes

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

Catalysed by AGXT2, SLC1A4inner side of the membrane, outer side of the membraneOne of 2 routes

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. Hippurate (Benzoylglycinate) Formation

Catalysed by AGXT2mitochondrial matrixOne of 2 routes

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. gamma-glutamyltransferase (alanine)

Catalysed by AGXT2, GGTLC3, GGT1, GGT5 and 3 morecytosolOne of 2 routes

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by AGXT2, MOCOS

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

Catalysed by AGXT2One of 2 routes

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. Glycodeoxycholate amidohydrolase

Catalysed by AGXT2cytosolOne of 2 routes

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

Catalysed by AGXT2, GLYATL2

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

Catalysed by AGXT2, BAAT

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

Catalysed by AGXT2, BAAT

1. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
2. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

Catalysed by AGXT2, BAAT

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. transport of alanine and tryptophan (cytosol to extracellular)
3. beta-carboline hydrolysis

Catalysed by AGXT2, SLC7A5extracellular space, cytosol

1. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. Carnitine O-Palmitoyltransferase

Catalysed by AGXT2