sn-glycerol 3-phosphocholine

Three steps

• anilineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by GPCPD1, CHAT, NAT2, NAT1cytosol

• CHEBI:17312Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by GPCPD1, CHATcytosolOne of 2 routes

• 5'-deoxyadenosineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by GPCPD1, CHDH, CDK5RAP1cytosolOne of 4 routes

• L-cysteineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by GPCPD1, CHAT, NAGScytosol, mitochondrial matrixOne of 3 routes

• a sphingomyelinReach from here →
  1. sn-Glycero-3-phosphocholine cholinephosphohydrolase
  2. CTP:choline-phosphate cytidylyltransferase
  3. ceramide cholinephosphotransferase (CDP-choline)

  Catalysed by ENPP6, PCYT1A, PCYT1Bcytosol, endoplasmic reticulum

• 3,3',5'-triiodo-L-thyronine sulfateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3,3',5'-triiodo-L-thyronine sulfate + iodide + A + H(+) = L-thyroxine sulfate + AH2

  Catalysed by GPCPD1, CHDH, DIO1cytosol

• 3,3'-diiodo-L-thyronineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2

  Catalysed by GPCPD1, CHDH, DIO1, DIO3cytosolOne of 2 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2

  Catalysed by GPCPD1, CHDH, DIO1cytosolOne of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by GPCPD1, CHAT, HADHA, ACADVL and 1 morecytosol, mitochondrial matrix

• glycine betaineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline dehydrogenase (choline)
  3. p-cumic alcohol:NAD+ oxidoreductase

  Catalysed by GPCPD1, CHDH, ALDH7A1cytosolOne of 7 routes

• CHEBI:17895Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by GPCPD1, SLC5A7, SLC6A14cytosol, extracellular spaceOne of 2 routes

• CHEBI:17927Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by GPCPD1, CHATcytosol

• CHEBI:18019Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by GPCPD1, SLC5A7, SLC6A14cytosol, extracellular space

• L-glutamineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by GPCPD1, SLC5A7, SLC6A14cytosol, extracellular space

• CHEBI:18095Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by GPCPD1, SLC5A7, CLTRN, SLC6A20cytosol, extracellular space

• keto-D-fructose 1-phosphateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase
  3. D-fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase

  Catalysed by GPCPD1, GPD2, ALDOA, ALDOB and 1 morecytosol, mitochondrial matrix

• N-carbamoyl-beta-alanineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by GPCPD1, SLC5A7cytosol, extracellular spaceOne of 2 routes

• 3',5'-diiodo-L-thyronineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2

  Catalysed by GPCPD1, CHDH, DIO3cytosol

• 1-(9Z,12Z,15Z-octadecatrienoyl)-3-(9Z-octadecenoyl)-glycerolReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)
  2. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  3. 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-(9Z,12Z,15Z-octadecatrienoyl)-3-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by ENPP6, PLA2G4A, MOGAT2, MOGAT1

• 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-3-(9Z-octadecenoyl)-glycerolReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)
  2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  3. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-3-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by ENPP6, PLA2G4A, MOGAT2

• (5Z)-dodecenoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by GPCPD1, CHAT, HADHA, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• 3-iodothyronamineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2

  Catalysed by GPCPD1, CHDH, DIO1, DIO3cytosolOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes

• 3-iodo-L-thyronineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3-iodo-L-thyronine + iodide + A + H(+) = 3,5-diiodo-L-thyronine + AH2

  Catalysed by GPCPD1, CHDH, DIO1, DIO3cytosolOne of 2 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 8 routes

• 3'-iodo-L-thyronineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3'-iodo-L-thyronine + iodide + A + H(+) = 3',5'-diiodo-L-thyronine + AH2

  Catalysed by GPCPD1, CHDH, DIO1, DIO2cytosolOne of 2 routes

• L-thyronineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2

  Catalysed by GPCPD1, CHDH, DIO3cytosol

• thyronamineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2

  Catalysed by GPCPD1, CHDH, DIO3cytosol

• 3'-iodothyronamineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2

  Catalysed by GPCPD1, CHDH, DIO1, DIO2cytosolOne of 2 routes

• 3,3'-diiodothyronamineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by GPCPD1, CHDH, DIO1, DIO2cytosolOne of 2 routes

• 3',5'-diiodothyronamineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by GPCPD1, CHDH, DIO3cytosol

• 3,3',5'-triiodothyronamineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2

  Catalysed by GPCPD1, CHDH, DIO3cytosol

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by GPCPD1, CHAT, HADHA, ACADVL and 1 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by GPCPD1, CHAT, HADHA, ACADVL and 1 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by GPCPD1, CHAT, ECHS1, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by GPCPD1, CHAT, ECHS1, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:240943Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by GPCPD1, SLC5A7, SLC6A5cytosol, extracellular spaceOne of 2 routes

• hypochlorous acidReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. Peroxidase

  Catalysed by GPCPD1, SLC5A7, LPOcytosol, extracellular spaceOne of 4 routes

• octadecanoateReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)
  2. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  3. 1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + sn-glycerol 3-phosphocholine + H(+)

  Catalysed by ENPP6, PLA2G4A, LYPLA2, ASPG

• potassium atomReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by GPCPD1, SLC5A7, SLC12A2, SLC12A1cytosol, extracellular spaceOne of 2 routes

• CHEBI:27540Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by GPCPD1, CHAT, ACSM4, ACSM1 and 4 morecytosolOne of 6 routes

• elaidic acidReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes

• CHEBI:28701Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by GPCPD1, CHAT, ACAA1, SCP2 and 1 morecytosol, peroxisomeOne of 7 routes

• a fatty acidReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)
  2. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  3. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)

  Catalysed by ENPP6, LIPEOne of 2 routes

• CHEBI:29052Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase
  3. D-glyceraldehyde-3-phosphate aldose-ketose-isomerase

  Catalysed by GPCPD1, GPD2, TPI1cytosol, mitochondrial matrix

• a carboxylateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. an acylcholine + H2O = a carboxylate + choline + H(+)
  3. an acylcholine + H2O = a carboxylate + choline + H(+)

  Catalysed by GPCPD1, BCHEcytosol

• hydrogenselenideReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)

  Catalysed by GPCPD1, CHDH, SCLYcytosol

• acetateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Acetylcholine aectylhydrolase

  Catalysed by GPCPD1, CHAT, BCHE, ACHEcytosolOne of 3 routes

• formic acidReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by GPCPD1, SLC5A7, SLC26A4cytosol, extracellular spaceOne of 2 routes

• malonic acidReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. Malonate Transport, Antiport with Chloride

  Catalysed by GPCPD1, SLC5A7cytosol, extracellular spaceOne of 2 routes