sulfate

Three steps

• prostaglandin A2-S-(S)-glutathioneReach from here →
  1. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. prostaglandin A2 + glutathione = prostaglandin A2-S-(S)-glutathione

  Catalysed by SLC25A14, SLC25A30, TSTD1, GSTP1 and 1 moreinner side of the membrane, outer side of the membrane

• prostaglandin J2-S-(R)-glutathioneReach from here →
  1. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. prostaglandin J2 + glutathione = prostaglandin J2-S-(R)-glutathione

  Catalysed by SLC25A14, SLC25A30, TSTD1, GSTA1 and 2 moreinner side of the membrane, outer side of the membrane

• prostaglandin J2-S-(S)-glutathioneReach from here →
  1. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. prostaglandin J2 + glutathione = prostaglandin J2-S-(S)-glutathione

  Catalysed by SLC25A14, SLC25A30, TSTD1, GSTP1 and 1 moreinner side of the membrane, outer side of the membrane

• hypothiocyanous acidReach from here →
  1. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  2. thiosulfate:cyanide sulfurtranserase
  3. Dihydrolipoyl Dehydrogenase

  Catalysed by SLC25A14, SLC25A30, SLC26A1, SLC25A10 and 3 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, extracellular spaceOne of 4 routes

• N-(9Z-octadecenoyl)glycineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, GLYATL3 and 1 moreextracellular space, cytosol

• N-(9Z-octadecenoyl)-L-phenylalanineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O

  Catalysed by SLC26A6, SLC6A14, PM20D1extracellular space, cytosol

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

  Catalysed by SLC26A6, SLC6A14, PM20D1extracellular space, cytosol

• N-(9Z-octadecenoyl)-L-leucineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and leucine (cytosol to extracellular)
  3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

  Catalysed by SLC26A6, SLC6A14, PM20D1extracellular space, cytosol

• N-octadecanoylglycineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• N-(9Z-hexadecenoyl)-glycineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. (9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• a 1,4-benzosemiquinoneReach from here →
  1. transport of fumarate and sulfate (cytosol to mitochondria)
  2. a quinone + succinate = fumarate + a quinol
  3. 2 a quinone + NADPH + H(+) = 2 a 1,4-benzosemiquinone + NADP(+)

  Catalysed by SLC25A10, SDHB, CRYZ, TP53I3 and 2 moremitochondrial matrix, cytosol

• estrone 3-O-(beta-D-glucuronate)Reach from here →
  1. estrone 3-sulfate + H2O = estrone + sulfate + H(+)
  2. Estrone 3-sulfate sulfohydrolase
  3. UDPglucuronate beta-D-glucuronosyltransferase(acceptor-unspecific)

  Catalysed by STS, UGT1A1, UGT1A10, UGT1A8cytosol, endoplasmic reticulumOne of 2 routes

• 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate)Reach from here →
  1. steroid sulfatase (5-alpha-dihydrotestosterone)
  2. steroid sulfatase (5-alpha-dihydrotestosterone)
  3. glucuronosyltransferase (5-alpha-dihydrotestosterone)

  Catalysed by STS, UGT2B4, UGT1A1, UGT2B28 and 2 morecytosol, endoplasmic reticulumOne of 2 routes

• acetoacetateReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. transport of acetoacetate and pyruvate (cytosol to mitochondria)

  Catalysed by SLC25A10, ME2, ME3mitochondrial matrix, cytosolOne of 8 routes

• (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoateReach from here →
  1. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate

  Catalysed by SLC25A14, SLC25A30, TSTD1, GSTM4 and 1 moreinner side of the membrane, outer side of the membrane

• a phenyl acetateReach from here →
  1. an aryl sulfate + H2O = a phenol + sulfate + H(+)
  2. an aryl sulfate + H2O = a phenol + sulfate + H(+)
  3. a phenyl acetate + H2O = a phenol + acetate + H(+)

  Catalysed by ARSL, ARSF, ARSK, SULF2 and 5 more

• 3-sulfinopyruvateReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase

  Catalysed by SLC25A14, SLC25A30, SLC25A12, SLC25A13 and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• S-methyl glutathioneReach from here →
  1. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. apo-[alkylcobalamin reductase] + methylcob(III)alamin + glutathione = S-methyl glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

  Catalysed by SLC25A14, SLC25A30, TSTD1, MMACHCinner side of the membrane, outer side of the membrane

• N-hexadecanoylglycineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, GLYATL3extracellular space, cytosol

• N-dodecanoylglycineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• N-decanoylglycineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• N-octanoylglycineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• N-octanoyl-(2S)-hydroxyglycineReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. N-octanoyl-(2S)-hydroxyglycine = octanamide + glyoxylate

  Catalysed by SLC25A10, CLYBL, PAMmitochondrial matrix, cytosol

• N-decanoyl-(2S)-hydroxyglycineReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. N-decanoyl-(2S)-hydroxyglycine = decanamide + glyoxylate

  Catalysed by SLC25A10, CLYBL, PAMmitochondrial matrix, cytosol

• N-dodecanoyl-(2S)-hydroxyglycineReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate

  Catalysed by SLC25A10, CLYBL, PAMmitochondrial matrix, cytosol

• N-tetradecanoyl-(2S)-hydroxyglycineReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate

  Catalysed by SLC25A10, CLYBL, PAMmitochondrial matrix, cytosol

• N-(9Z-octadecenoyl)-(2S)-hydroxyglycineReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. N-(9Z-octadecenoyl)-(2S)-hydroxyglycine = (9Z)-octadecenamide + glyoxylate

  Catalysed by SLC25A10, CLYBL, PAMmitochondrial matrix, cytosol

• N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycineReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine = (9Z,12Z,15Z)-octadecatrienamide + glyoxylate

  Catalysed by SLC25A10, CLYBL, PAMmitochondrial matrix, cytosol

• L-homoarginineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)

  Catalysed by SLC26A6, SLC6A14, SLC25A29extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-homocarnosineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and histidine (cytosol to extracellular)
  3. Formation of homocarnosine

  Catalysed by SLC26A6, SLC6A14, CARNS1extracellular space, cytosolOne of 3 routes

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, GARTextracellular space, cytosol

• L-cystine-bis-glycineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by SLC26A6, SLC6A9, SLC6A14, DPEP1 and 1 moreextracellular space, cytosolOne of 2 routes

• glycyldehydrophenylalanineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by SLC26A6, SLC6A9, SLC6A14, DPEP1extracellular space, cytosol

• S-adenosylglutathioneReach from here →
  1. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. apo-[alkylcobalamin reductase] + adenosylcob(III)alamin + glutathione = S-adenosylglutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

  Catalysed by SLC25A14, SLC25A30, TSTD1, MMACHCinner side of the membrane, outer side of the membrane

• 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

  Catalysed by SLC26A6, SLC6A14, PFASextracellular space, cytosol

• kinetensinReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. Chymase

  Catalysed by SLC26A6, SLC6A14, CMA1extracellular space, cytosolOne of 3 routes

• an N-(fatty acyl)-glycineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• (7Z)-octadecenoyl-CoAReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

  Catalysed by SLC25A14, SLC25A30, NAT8L, CPT1A and 2 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 3 routes

• acetaldehydeReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Transport of L-Threonine by Atb0 Transporter
  3. L-threonine acetaldehyde-lyase (glycine-forming)

  Catalysed by SLC26A6, SLC6A14extracellular space, cytosol

• CHEBI:15345Reach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by SLC25A14, SLC25A30, NAT8L, AACSinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• acetylcholineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by SLC26A6, SLC5A7, CHATextracellular space, cytosolOne of 5 routes

• acetylpyruvateReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. acetylpyruvate + H2O = acetate + pyruvate + H(+)

  Catalysed by SLC25A10, ME2, ME3, FAHD1mitochondrial matrix, cytosol

• all-trans-retinoic acidReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. transport of pyruvate and retinoate (cytosol to extracellular)

  Catalysed by SLC25A10, ME2, ME3, SLC16A4 and 5 moremitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase(4-hydroxylating)

  Catalysed by SLC26A6, SLC6A14, PAHextracellular space, cytosolOne of 3 routes

• CHEBI:15380Reach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by SLC25A14, SLC25A30, NAT8L, ALAS1 and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. 2-Methylbutyrylglycine Transport, Extracellular
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by SLC26A6, SLC6A5, GLYAT, GLYATL2 and 1 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Production of Tiglylcarnitine

  Catalysed by SLC25A14, SLC25A30, NAT8L, CPT1A and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• isobutyryl-CoAReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by SLC25A14, SLC25A30, NAT8L, HADHA and 2 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by SLC25A14, SLC25A30, NAT8L, GLYATinner side of the membrane, outer side of the membrane, mitochondrial matrix