15(S)-HPETE

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

107 compounds within 3 steps: 3 in 1, 7 in 2, 97 in 3

Three steps

(5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol
(12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol
(15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol
(17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol
a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol
3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol
a quinolReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol
5(S)-HETEReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. Glutathione: 5-HPETE oxidoreductase
Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosolOne of 2 routes
CHEBI:28666Reach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. transport of GSH and LTD4 (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes
3-disulfanyl-L-alanineReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. cystine to cysteine conversion
3. L-cystine thiocysteine-lyase (deaminating
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol
L-ascorbic acidReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
Catalysed by GPX5, GPX1, GPX2, GPX3 and 9 morecytosol
glycocholateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. solute carrier organic anion transporter (glycocholate)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 3 routes
cholateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. solute carrier organic anion transporter (cholate)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 3 routes
hydrogen sulfideReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosolOne of 3 routes
L-aspartateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. cystine to cysteine conversion
3. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes
an alcoholReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol
(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. transport of arachidonate and GSH (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosol, extracellular spaceOne of 2 routes
serotoninReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. transport of GSH and serotonin (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes
glycochenodeoxycholateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, inner side of the membrane, outer side of the membrane
taurocholateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. solute carrier organic anion transporter (GSH)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 3 routes
glycolithocholic acidReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. transport of glycolithocholate and GSH (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes
tert-butanolReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol
gamma-Glu-AlaReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. gamma-glutamyltransferase (alanine)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 11 morecytosol, extracellular space
3,3',5-triiodo-L-thyronineReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. transport of GSH and triiodothyronine (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes
prostaglandin E1Reach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. transport of GSH and prostaglandin E1 (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes
prostaglandin I2Reach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. transport of GSH and prostaglandin I2 (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes
prostaglandin F2alphaReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes
prostaglandin H2Reach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. transport of GSH and prostaglandin H2 (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes
prostaglandin D2Reach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. transport of GSH and prostaglandin D2 (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes
leukotriene A4Reach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. transport of GSH and leukotriene A4 (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes
(R)-S-lactoylglutathioneReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosolOne of 3 routes
S-formylglutathioneReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. alcohol dehydrogenase (formaldehyde)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 11 morecytosolOne of 2 routes
L-alanineReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. cystine to cysteine conversion
3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular space
leukotriene C4Reach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. leukotriene C4 synthase (GSH)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosolOne of 5 routes
taurolithocholate 3-sulfateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. transport of GSH and sulfotaurolithocholate (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes
5-oxo-L-prolineReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. glutathione = L-cysteinylglycine + 5-oxo-L-proline
Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosol
histamineReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. transport of GSH and histamine (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes
L-thyroxineReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. transport of GSH and thyroxine (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes
S-sulfanylglutathioneReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. Sulfide:glutathione,quinone oxidoreductase
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, mitochondrial matrixOne of 6 routes
dopamineReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. transport of dopamine and GSH (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes
glycolithocholate 3-sulfateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes
prostaglandin E2Reach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. transport of GSH and prostaglandin E2 (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes
L-cysteinylglycineReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. glutathione gamma-glutamylaminopeptidase
Catalysed by GPX5, GPX1, GPX2, GPX3 and 11 morecytosolOne of 6 routes
ubiquinol-10Reach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol
(R)-noradrenalineReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. transport of GSH and noradrenaline (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes
20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes
(9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol
ursodeoxycholateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. transport of GSH and ursodeoxycholate (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular spaceOne of 2 routes
prostaglandin G2Reach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
3. transport of GSH and prostaglandin G2 (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes
glycodeoxycholateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
3. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, inner side of the membrane, outer side of the membrane